CAS 157212-55-0
:Bosentan monohydrate
Description:
Bosentan monohydrate is a pharmaceutical compound primarily used in the treatment of pulmonary arterial hypertension (PAH). It is classified as an endothelin receptor antagonist, specifically targeting both endothelin-1 receptors (ETA and ETB), which play a significant role in vasoconstriction and vascular remodeling. The monohydrate form indicates that the compound contains one molecule of water per molecule of bosentan, which can influence its solubility and stability. Bosentan is typically presented as a white to off-white crystalline powder and is soluble in water and organic solvents. Its molecular formula reflects a complex structure that includes a sulfonamide group, contributing to its pharmacological activity. The compound is administered orally and is known to have a relatively long half-life, allowing for once or twice daily dosing. Common side effects may include liver enzyme elevations and potential interactions with other medications, necessitating regular monitoring of liver function in patients. Overall, bosentan monohydrate is an important therapeutic agent in managing PAH, improving exercise capacity and overall quality of life for affected individuals.
Formula:C27H31N5O7S
InChI:InChI=1/C27H29N5O6S.H2O/c1-27(2,3)18-10-12-19(13-11-18)39(34,35)32-23-22(38-21-9-6-5-8-20(21)36-4)26(37-17-16-33)31-25(30-23)24-28-14-7-15-29-24;/h5-15,33H,16-17H2,1-4H3,(H,30,31,32);1H2
InChI key:InChIKey=SXTRWVVIEPWAKM-UHFFFAOYSA-N
SMILES:O(C=1C(NS(=O)(=O)C2=CC=C(C(C)(C)C)C=C2)=NC(=NC1OCCO)C=3N=CC=CN3)C4=C(OC)C=CC=C4.O
Synonyms:- 4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)(2,2'-bipyrimidin)-4-yl)benzenesulfonamide monohydrate
- 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide hydrate (1:1)
- Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2′-bipyrimidin]-4-yl]-, hydrate (1:1)
- Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2′-bipyrimidin]-4-yl]-, monohydrate
- Bosentan hydrate
- Stayveer
- Bosentan monohydrate
- Bosetan
- Bosentan hydrate USP/EP/BP
- CS-170
- Bosentan
- Bosentan (200 mg)
- 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-Methoxyphenoxy)-2-(pyriMidin-2-yl)pyriMidin-4-yl]benzene-1-sulfonaMide
- 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]benzene-1-sulfonamide hydrate
- See B675900
- See more synonyms
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Bosentan Monohydrate
CAS:Formula:C27H29N5O6S·H2OPurity:>98.0%(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:569.64Bosentan
CAS:Sulfonamides used as drugsFormula:C27H29N5O6S·H20Color and Shape:White Yellow PowderMolecular weight:551.18385Bosentan Hydrate
CAS:Bosentan HydrateFormula:C27H31N5O7SPurity:>99%Color and Shape:SolidMolecular weight:569.63Bosentan (hydrate)
CAS:Bosentan (hydrate)Formula:C27H29N5O6S·H2OPurity:≥98%Color and Shape:SolidMolecular weight:569.63Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-, hydrate(1:1)
CAS:Formula:C27H31N5O7SPurity:95%Color and Shape:SolidMolecular weight:569.6293Bosentan hydrate
CAS:Formula:C27H29N5O6S·xH2OPurity:≥ 98.0% (dried basis)Color and Shape:White to off-white, light-yellow or faint beige powderMolecular weight:569.63 (anhydrous)Bosentan Monohydrate
CAS:Controlled ProductFormula:C27H29N5O6S·H2OColor and Shape:NeatMolecular weight:569.63Bosentan Hydrate
CAS:Controlled ProductApplications Bosentan Hydrate, is an endothelin receptor antagonist, used as a vasodilator, and antihypertensive.
References Clozel, M., et al.: J. Pharmacol. Exp. Ther., 270, 228 (1994), Gutsch, G., et al.: Cardiovasc. Drugs Ther., 10, 717 (1996), Weber, C., et al.: Clin Pharmacol. Ther., 60, 124 (1996), Krum, H., et al.: N. Engl. J. Med., 338, 784 (1998)Formula:C27H29N5O6S·H2OColor and Shape:NeatMolecular weight:569.63Bosentan (hydrate)
CAS:Bosentan hydrate (Ro 47-0203) is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.Formula:C27H29N5O6S·H2OPurity:99.31% - 99.86%Color and Shape:SolidMolecular weight:569.63Bosentan hydrate
CAS:Endothelin receptor antagonist; vasodilatorFormula:C27H29N5O6S•H2OPurity:Min. 95%Color and Shape:PowderMolecular weight:569.63 g/molBosentan hydrate
CAS:4-(tert-Butyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide hydrateFormula:C27H31N5O7SPurity:98%Molecular weight:569.63
