The chemical substance known as "(1R,5S,6S)-6-[1(R)-Hydroxyethyl]-1-methyl-2-[2-oxopyrrolidin-4(R)-ylsulfanyl]-1-dethia-1-carba-2-penem-3-carboxylic acid pivaloyloxymethyl ester" with CAS number 157542-49-9 is a synthetic compound that belongs to the class of carbapenem antibiotics. This compound exhibits a complex stereochemistry, indicated by its multiple chiral centers, which contributes to its biological activity. The presence of a pivaloyloxymethyl ester group suggests that it may have enhanced lipophilicity, potentially improving its absorption and bioavailability. The structure includes a pyrrolidine ring and a sulfur atom, which are characteristic of certain antibiotic mechanisms, likely contributing to its efficacy against a range of bacterial pathogens. As a carbapenem, it is expected to possess broad-spectrum antibacterial properties, making it effective against both Gram-positive and Gram-negative bacteria. The specific functional groups and stereochemistry play crucial roles in its pharmacodynamics and pharmacokinetics, influencing its therapeutic potential and safety profile.

(1R,5S,6S)-6-[1(R)-Hydroxyethyl]-1-methyl-2-[2-oxopyrrolidin-4(R)-ylsulfanyl]-1-dethia-1-carba-2-penem-3-carboxylic acid pivaloyloxymethyl ester

157542-49-9: The chemical substance known as "(1R,5S,6S)-6-[1(R)-Hydroxyethyl]-1-methyl-2-[2-oxopyrrolidin-4(R)-ylsulfanyl]-1-dethia-1-carba-2-penem-3-carboxylic acid pivaloyloxymethyl ester" with CAS number 157542-49-9 is a synthetic compound that belongs to the class of carbapenem antibiotics. This compound exhibits a complex stereochemistry, indicated by its multiple chiral centers, which contributes to its biological activity. The presence of a pivaloyloxymethyl ester group suggests that it may have enhanced lipophilicity, potentially improving its absorption and bioavailability. The structure includes a pyrrolidine ring and a sulfur atom, which are characteristic of certain antibiotic mechanisms, likely contributing to its efficacy against a range of bacterial pathogens. As a carbapenem, it is expected to possess broad-spectrum antibacterial properties, making it effective against both Gram-positive and Gram-negative bacteria. The specific functional groups and stereochemistry play crucial roles in its pharmacodynamics and pharmacokinetics, influencing its therapeutic potential and safety profile.

<p>CS 834, a novel oral carbapenem antibiotic, is an ester prodrug of the active metabolite R-95867.</p>

CAS 157542-49-9

(1R,5S,6S)-6-[1(R)-Hydroxyethyl]-1-methyl-2-[2-oxopyrrolidin-4(R)-ylsulfanyl]-1-dethia-1-carba-2-penem-3-carboxylic acid pivaloyloxymethyl ester

CS 834

Ref: TM-T31106