CAS 157606-25-2

CECROPIN A (1-7)-MELITTIN A (2-9) AMIDE

Description:

CECROPIN A (1-7)-MELITTIN A (2-9) AMIDE, with CAS number 157606-25-2, is a synthetic peptide that combines elements from two different antimicrobial peptides: cecropin A and melittin A. Cecropin A is known for its broad-spectrum antimicrobial activity, particularly against bacteria and fungi, while melittin, derived from bee venom, exhibits potent hemolytic and antimicrobial properties. The hybridization of these peptides aims to enhance their antimicrobial efficacy and stability. This compound typically exhibits amphipathic characteristics, allowing it to interact with lipid membranes, leading to membrane disruption in target pathogens. Its structure often includes a positively charged region that facilitates binding to negatively charged bacterial membranes. The amide modification at the terminal end can improve its stability and bioavailability. Due to its potential applications in developing new antimicrobial agents, CECROPIN A (1-7)-MELITTIN A (2-9) AMIDE is of interest in pharmaceutical and biotechnological research, particularly in the context of combating antibiotic-resistant infections.

Formula: C₈₉H₁₅₂N₂₂O₁₅

Synonyms:

• Lys-Trp-Lys-Leu-Phe-Lys-Lys-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Nh2
• H-Lys-Trp-Lys-Leu-Phe-Lys-Lys-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Nh2
• Cecropin A (1-8)-Melittin A (3-9) Amide
• Cecropin A-Melittin Hybrid Peptide
• Ca(1-7)M(2-9)Nh2
• Cecropin A-melittin hybrid peptide [CA(1-7)M(2-9)NH2]
• Oct-CA(1-7)M(2-9)
• Cecropin A (1-7)-Melittin A (2-9) amide , Cecropin A (1-8)-Melittin A (3-9) amide
• Cecropin A (1-7)-Melittin A (2-9) aMide
• Cecropin A (1-7)-Melittin A (2-9) amide/Cecropin A (1-8)-Melittin A (3-9) amide, CAMEL0, CM15, Cecropin A-melittin hybrid peptide [CA(1-7)M(2-9)NH2]
• CAMEL0, Cecropin A (1-8)-Melittin A (3-9) aMide, CM15
• L-Leucinamide,L-lysyl-L-tryptophyl-L-lysyl-L-leucyl-L-phenylalanyl-L-lysyl-L-lysyl-L-isoleucylglycyl-L-alanyl-L-valyl-L-leucyl-L-lysyl-L-valyl-
• CECROPIN A (1-7)-MELITTIN A (2-9) AMIDE

Cecropin A (1-7)-Melittin A (2-9) amide

CAS: 157606-25-2

Cecropin A (1-7)-Melittin A (2-9) amide, also referred to as CAMEL0, is a synthetic hybrid peptide that is composed of portions of the naturally occurring antibiotic peptide cecropin A and melittin. CAMEL0 shows a better antimicrobial activity than the native molecules, but lacks the hemolytic properties of melittin. Studies revealed that the range of its antimicrobial activity is not only restricted to aerobic microorganisms but also included several gram-negative and gram-positive anaerobic microorganisms. Through its ascertained broad spectrum of antibiotic activity, this hybrid peptide may also represent an effective substitute for ciprofloxacin in the treatment of anthrax infections.

Formula: C₈₉H₁₅₂N₂₂O₁₅

Purity: 98.3%

Color and Shape: White

Molecular weight: 1770.33

Ref: 01-4042609

Cecropin A (1-7)-Melittin A (2-9)

CAS: 157606-25-2

Cecropin A-Melittin peptide combats Gram+ & Gram- bacteria, has antimalarial effects, no hemolysis like bee venom.

Formula: C₈₉H₁₅₂N₂₂O₁₅

Color and Shape: Solid

Molecular weight: 1770.3

Ref: TM-T76468

Cecropin A (1-7)-Melittin A (2-9) amide trifluoroacetate salt

CAS: 157606-25-2

Cecropin A (1-7)-Melittin A (2-9) amide trifluoroacetate salt is a cecropin-melittin hybrid peptide that has been immobilized on cellulose nanofibers for use as an antimicrobial. It has been shown to have strong antimicrobial activity against bacillus subtilis, and the immobilization process ensures that the peptide is not released from the surface of the material. The process of coating with nanopaper and then applying the peptides provides a stable surface with high antimicrobial activity. The synthetic peptides are synthesized by solid phase synthesis using Fmoc chemistry and purified by preparative HPLC.

Formula: C₈₉H₁₅₂N₂₂O₁₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 1,770.3 g/mol

Ref: 3D-FC109665