CAS 15763-06-1

1-Methyladenosine

Description:

1-Methyladenosine is a naturally occurring nucleoside derivative of adenosine, characterized by the presence of a methyl group attached to the nitrogen atom at the first position of the adenine base. This modification plays a crucial role in various biological processes, particularly in RNA metabolism and regulation. It is involved in the post-transcriptional modification of RNA, influencing RNA stability, splicing, and translation. The presence of the methyl group can affect the interaction of RNA with proteins and other molecules, thereby impacting gene expression and cellular function. 1-Methyladenosine is also a component of certain tRNA molecules, contributing to their proper functioning during protein synthesis. In terms of solubility, it is generally soluble in water and polar solvents, which is typical for nucleosides. Its chemical structure includes a ribose sugar linked to the modified adenine base, and it can be analyzed using various techniques such as chromatography and mass spectrometry. Overall, 1-methyladenosine is significant in the field of molecular biology and biochemistry due to its regulatory roles in cellular processes.

Formula: C₁₁H₁₅N₅O₄

InChI: InChI=1S/C11H15N5O4/c1-15-3-14-10-6(9(15)12)13-4-16(10)11-8(19)7(18)5(2-17)20-11/h3-5,7-8,11-12,17-19H,2H2,1H3/t5-,7-,8-,11-/m1/s1

InChI key: InChIKey=GFYLSDSUCHVORB-IOSLPCCCSA-N

SMILES: O[C@H]1[C@H](N2C3=C(N=C2)C(=N)N(C)C=N3)O[C@H](CO)[C@H]1O

Synonyms:

• (6Z)-1-methyl-9-pentofuranosyl-1,9-dihydro-6H-purin-6-imine
• 1-Methyladenosine
• 9H-Purine, 1,6-dihydro-6-imino-1-methyl-9-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
• Adenosine, 1-methyl-
• Adenosine, 1-methyl- (VAN) (8CI)
• Adenosine, N,6-didehydro-1,6-dihydro-1-methyl- (9CI)
• N1-Methyladenosine
• N¹-Methyladenosine
• Nsc 92165
• 9H-Purine, 1,6-dihydro-6-imino-1-methyl-9-β-D-ribofuranosyl-

Adenosine, 1-methyl-

CAS: 15763-06-1

Formula: C₁₁H₁₅N₅O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 281.2679

Ref: IN-DA001PKM

(2R,3R,4S,5R)-2-(6-Amino-1-Methyl-1H-Purin-9(2H)-Yl)-5-(Hydroxymethyl)Tetrahydrofuran-3,4-Diol

CAS: 15763-06-1

(2R,3R,4S,5R)-2-(6-Amino-1-Methyl-1H-Purin-9(2H)-Yl)-5-(Hydroxymethyl)Tetrahydrofuran-3,4-Diol

Purity: 95%

Molecular weight: 283.28g/mol

Ref: 54-OR1025807

1-Methyladenosine

CAS: 15763-06-1

1-Methyladenosine

Purity: ≥98%

Molecular weight: 281.27g/mol

Ref: 54-BUP11845

N1-Methyladenosine

CAS: 15763-06-1

Formula: C₁₁H₁₅N₅O₄

Purity: ≥ 98.0% (HPLC)

Color and Shape: White to off-white crystalline powder

Molecular weight: 281.77

Ref: 7W-GN7727

1-METHYLADENOSINE

CAS: 15763-06-1

Purity: 95%

Molecular weight: 281.272003173828

Ref: 10-F805080

1-Methyladenosine

CAS: 15763-06-1

1-Methyladenosine (M1A) belongs to the class of organic compounds known as purine nucleosides.

Formula: C₁₁H₁₅N₅O₄

Purity: 99.84% - >99.99%

Color and Shape: Solid

Molecular weight: 281.27

Ref: TM-T7571

Adenosine Impurity 19

CAS: 15763-06-1

Formula: C₁₁H₁₅N₅O₄

Molecular weight: 281.27

Ref: 4Z-A-267136

1-Methyl Adenosine-d3

Controlled Product

CAS: 15763-06-1

Applications 1-Methyl Adenosine-d3 is the isotope labelled analog of 1-Methyl Adenosine (M285065); a modified adenosine molecule created through the processing of tRNA by methyltransferases. The presence seen to be elevated in the urinary excretion of cancer patients. Thus it may be an early diagnosis biomarker.
References Wu, Q. et al.: Anal. Chem., 86, 10122 (2014); Puri, P. et al.: Mol. Microbiol., 93, 944 (2014)

Formula: C₁₁H₁₂D₃N₅O₄

Color and Shape: Neat

Molecular weight: 284.29

Ref: TR-M285067

1-Methyl Adenosine

Controlled Product

CAS: 15763-06-1

Formula: C₁₁H₁₅N₅O₄

Color and Shape: Neat

Molecular weight: 281.27

Ref: TR-M285065

N1-Methyladenosine

CAS: 15763-06-1

N1-Methyladenosine is a nucleoside that has been shown to inhibit the synthesis of proteins in the ribosome, which are essential for all cellular functions. N1-Methyladenosine has been shown to be effective against HIV infection, and has also been used as a chemotherapeutic agent in cancer cells. The optimum concentration of this drug is unknown, but it is known that at high concentrations, it can cause cellular death. N1-Methyladenosine has also been shown to be effective in treating metabolic disorders and autoimmune diseases.

Formula: C₁₁H₁₅N₅O₄

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 281.27 g/mol

Ref: 3D-NM03697