Fmoc-Phe-Ser(tBu)-OH, with the CAS number 157675-78-0, is a protected amino acid derivative commonly used in peptide synthesis. The "Fmoc" (9-fluorenylmethoxycarbonyl) group serves as a protective moiety for the amino group, allowing for selective reactions during peptide assembly. The "Phe" indicates the presence of phenylalanine, an aromatic amino acid that contributes to the hydrophobic character of the peptide. The "Ser(tBu)" denotes serine with a tert-butyl (tBu) protecting group on its hydroxyl side chain, which enhances stability and solubility during synthesis. This compound is typically utilized in solid-phase peptide synthesis (SPPS), where the protection and deprotection of functional groups are crucial for the successful assembly of peptides. Its characteristics include good solubility in organic solvents, stability under standard laboratory conditions, and compatibility with various coupling reagents. Overall, Fmoc-Phe-Ser(tBu)-OH is an important building block in the field of peptide chemistry, facilitating the synthesis of complex peptides for research and therapeutic applications.

Fmoc-Phe-Ser(tBu)-OH

157675-78-0: Fmoc-Phe-Ser(tBu)-OH, with the CAS number 157675-78-0, is a protected amino acid derivative commonly used in peptide synthesis. The "Fmoc" (9-fluorenylmethoxycarbonyl) group serves as a protective moiety for the amino group, allowing for selective reactions during peptide assembly. The "Phe" indicates the presence of phenylalanine, an aromatic amino acid that contributes to the hydrophobic character of the peptide. The "Ser(tBu)" denotes serine with a tert-butyl (tBu) protecting group on its hydroxyl side chain, which enhances stability and solubility during synthesis. This compound is typically utilized in solid-phase peptide synthesis (SPPS), where the protection and deprotection of functional groups are crucial for the successful assembly of peptides. Its characteristics include good solubility in organic solvents, stability under standard laboratory conditions, and compatibility with various coupling reagents. Overall, Fmoc-Phe-Ser(tBu)-OH is an important building block in the field of peptide chemistry, facilitating the synthesis of complex peptides for research and therapeutic applications.

<p>Fmoc-Phe-Ser(tBu)-OH is a pentafluorophenyl ester of the amino acid phenylalanine. It is used in solid-phase peptide synthesis to link amines and carboxylic acids. Fmoc-Phe-Ser(tBu)-OH is used as an intermediate in the synthesis of peptides with a C-terminal amidated or methyl esters. The coupling reaction is catalyzed by 1-hydroxybenzotriazole (HOBT) and N,N'-dicyclohexylcarbodiimide (DCC). HOBT reacts with the hydroxyl group on the β carbon of the ester to form an acetoxy group, which reacts with the amine on the opposite side of the peptide chain to form a new amide bond. DCC reacts with both reactive groups, forming an iminoester intermediate. This intermediate can be hydroly</p>

CAS 157675-78-0

Fmoc-Phe-Ser(tBu)-OH

Fmoc-Phe-Ser(tBu)-OH

Ref: IN-DA001PMH

Fmoc-Phe-Ser(tBu)-OH

Ref: 3D-FF111292