CAS 157716-52-4: Perifosine

Description: Perifosine, with the CAS number 157716-52-4, is an alkylphospholipid compound that has garnered attention for its potential as an anticancer agent. It functions primarily as a modulator of cell signaling pathways, particularly by inhibiting the Akt pathway, which is often dysregulated in various cancers. Perifosine is characterized by its ability to induce apoptosis in cancer cells and inhibit tumor growth. It is typically administered orally and has been studied in various clinical trials for its efficacy against multiple types of malignancies, including colorectal and breast cancers. The compound is known for its relatively low toxicity compared to traditional chemotherapeutics, making it a candidate for combination therapies. Additionally, perifosine's mechanism of action involves altering membrane dynamics and affecting lipid metabolism, which contributes to its therapeutic effects. As research continues, perifosine remains a subject of interest in the field of oncology, particularly in the context of targeted cancer therapies.

Formula: C₂₅H₅₂NO₄P

InChI: InChI=1S/C25H52NO4P/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24-29-31(27,28)30-25-20-22-26(2,3)23-21-25/h25H,4-24H2,1-3H3

InChI key: InChIKey=SZFPYBIJACMNJV-UHFFFAOYSA-N

SMILES: O=P([O-])(OCCCCCCCCCCCCCCCCCC)OC1CC[N+](C)(C)CC1

Synonyms:

• (1,1-Dimethylpiperidin-1-ium-4-yl) octadecyl phosphate
• 1,1-Dimethylpiperidinium-4-yl octadecyl phosphate
• 1,1-Dimethylpiperidinium-4-yl-octadecylphosphat
• 4-[[Hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethylpiperidinium Inner Salt
• 4-{[Hydroxy(Octadecyloxy)Phosphoryl]Oxy}-1,1-Dimethylpiperidinium
• D 21266
• Krx 0401
• NSC 639966
• Perifosine [INN]
• Piperidinium, 4-[[Hydroxy(Octadecyloxy)Phosphinyl]Oxy]-1,1-Dimethyl-, Inner Salt
• Perifosine

Piperidinium, 4-[[hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethyl-, inner salt

CAS: 157716-52-4

• Formula: C₂₅H₅₂NO₄P
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 461.65844100000004

Perifosine

CAS: 157716-52-4

• Purity: 99.93%
• Molecular weight: 461.66g/mol

Perifosine

CAS: 157716-52-4

• Formula: C₂₅H₅₂NO₄P
• Purity: >98.0%(HPLC)
• Color and Shape: White to Almost white powder to crystal
• Molecular weight: 461.67

Perifosine

CAS: 157716-52-4

Perifosine (KRX-0401) is an oral-active, alkyl-phosphocholine Akt inhibitor with potential antineoplastic activity.

• Formula: C₂₅H₅₂NO₄P
• Purity: 100% - 99.94%
• Color and Shape: Solid
• Molecular weight: 461.66

Perifosine

CAS: 157716-52-4

• Molecular weight: 461.66g/mol

1,1-Dimethylpiperidin-1-ium-4-yl octadecyl phosphate

CAS: 157716-52-4

• Purity: 95.0%
• Molecular weight: 461.6679992675781

Perifosine

CAS: 157716-52-4

Applications Antineoplastic. References Block, M., et al.: Anti. Res., 30, 2025 (2010), Carrasco, M., et …

• Formula: C₂₅H₅₂NO₄P
• Color and Shape: Neat
• Molecular weight: 461.66

Perifosine

CAS: 157716-52-4

Protein kinase B/Akt and MAP kinase inhibitor; anti-proliferative

• Formula: C₂₅H₅₂NO₄P
• Purity: Min. 95%
• Molecular weight: 461.66 g/mol