CAS 157716-52-4

Perifosine

Description:

Perifosine, with the CAS number 157716-52-4, is an alkylphospholipid compound that has garnered attention for its potential as an anticancer agent. It functions primarily as a modulator of cell signaling pathways, particularly by inhibiting the Akt pathway, which is often dysregulated in various cancers. Perifosine is characterized by its ability to induce apoptosis in cancer cells and inhibit tumor growth. It is typically administered orally and has been studied in various clinical trials for its efficacy against multiple types of malignancies, including colorectal and breast cancers. The compound is known for its relatively low toxicity compared to traditional chemotherapeutics, making it a candidate for combination therapies. Additionally, perifosine's mechanism of action involves altering membrane dynamics and affecting lipid metabolism, which contributes to its therapeutic effects. As research continues, perifosine remains a subject of interest in the field of oncology, particularly in the context of targeted cancer therapies.

Formula: C₂₅H₅₂NO₄P

InChI: InChI=1S/C25H52NO4P/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24-29-31(27,28)30-25-20-22-26(2,3)23-21-25/h25H,4-24H2,1-3H3

InChI key: InChIKey=SZFPYBIJACMNJV-UHFFFAOYSA-N

SMILES: O(P(OCCCCCCCCCCCCCCCCCC)(=O)[O-])C1CC[N+](C)(C)CC1

Synonyms:

• (1,1-Dimethylpiperidin-1-ium-4-yl) octadecyl phosphate
• 1,1-Dimethylpiperidinium-4-yl octadecyl phosphate
• 1,1-Dimethylpiperidinium-4-yl-octadecylphosphat
• 4-[[Hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethylpiperidinium Inner Salt
• 4-{[Hydroxy(Octadecyloxy)Phosphoryl]Oxy}-1,1-Dimethylpiperidinium
• D 21266
• Krx 0401
• NSC 639966
• Perifosine [INN]
• Piperidinium, 4-[[Hydroxy(Octadecyloxy)Phosphinyl]Oxy]-1,1-Dimethyl-, Inner Salt
• Perifosine

Perifosine

CAS: 157716-52-4

Formula: C₂₅H₅₂NO₄P

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 461.67

Ref: 3B-P2831

Piperidinium, 4-[[hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethyl-, inner salt

CAS: 157716-52-4

Formula: C₂₅H₅₂NO₄P

Purity: 98%

Color and Shape: Solid

Molecular weight: 461.6584

Ref: IN-DA001PNU

Perifosine

CAS: 157716-52-4

Perifosine

Purity: ≥98%

Molecular weight: 461.66g/mol

Ref: 54-BUP02110

Perifosine

CAS: 157716-52-4

Perifosine

Purity: 98%

Molecular weight: 461.66g/mol

Ref: 54-BIFK0035

Perifosine

CAS: 157716-52-4

Perifosine (KRX-0401) is an oral-active, alkyl-phosphocholine Akt inhibitor with potential antineoplastic activity.

Formula: C₂₅H₅₂NO₄P

Purity: 99.94% - >99.99%

Color and Shape: Solid

Molecular weight: 461.66

Ref: TM-T2492

1,1-Dimethylpiperidin-1-ium-4-yl octadecyl phosphate

CAS: 157716-52-4

Formula: C₂₅H₅₂NO₄P

Purity: 98%

Molecular weight: 461.668

Ref: 10-F091523

Perifosine

Controlled Product

CAS: 157716-52-4

Applications Antineoplastic.
References Block, M., et al.: Anti. Res., 30, 2025 (2010), Carrasco, M., et al.: Brit. J. Pharmacol., 160, 355 (2010), Munoz-Martinez, F., et al.: Biochem. Pharmacol., 80, 793 (2010),

Formula: C₂₅H₅₂NO₄P

Color and Shape: Neat

Molecular weight: 461.66

Ref: TR-P287380

Perifosine

CAS: 157716-52-4

Protein kinase B/Akt and MAP kinase inhibitor; anti-proliferative

Formula: C₂₅H₅₂NO₄P

Purity: Min. 95%

Molecular weight: 461.66 g/mol

Ref: 3D-FP26843