CAS 15793-38-1

Quinazosin

Description:

Quinazosin is a pharmaceutical compound primarily classified as an alpha-1 adrenergic antagonist, which is used mainly in the treatment of hypertension and benign prostatic hyperplasia. It works by blocking alpha-1 receptors, leading to vasodilation and a subsequent decrease in blood pressure. Quinazosin is characterized by its chemical structure, which includes a quinazoline ring system, contributing to its pharmacological activity. The compound is typically administered orally and has a relatively long half-life, allowing for once-daily dosing in clinical settings. It is known for its potential side effects, which may include dizziness, fatigue, and orthostatic hypotension, particularly upon initiation of therapy. Quinazosin is also notable for its selectivity towards alpha-1 receptors, making it a useful agent in managing conditions related to smooth muscle contraction. As with any medication, it is essential to consider patient-specific factors and potential drug interactions when prescribing Quinazosin.

Formula: C₁₇H₂₃N₅O₂

InChI: InChI=1/C17H23N5O2/c1-4-5-21-6-8-22(9-7-21)17-19-13-11-15(24-3)14(23-2)10-12(13)16(18)20-17/h4,10-11H,1,5-9H2,2-3H3,(H2,18,19,20)

InChI key: InChIKey=HSIPLPKNLDWHSE-UHFFFAOYSA-N

SMILES: NC=1C2=C(N=C(N1)N3CCN(CC=C)CC3)C=C(OC)C(OC)=C2

Synonyms:

• 2-(4-Allyl-1-piperazinyl)-4-amino-6,7-dimethoxyquinazoline
• 2-(4-Allylpiperazin-1-yl)-6,7-dimethoxyquinazolin-4-amine
• 4-Quinazolinamine, 6,7-dimethoxy-2-[4-(2-propen-1-yl)-1-piperazinyl]-
• 4-Quinazolinamine, 6,7-dimethoxy-2-[4-(2-propenyl)-1-piperazinyl]-
• 6,7-Dimethoxy-2-[4-(2-propen-1-yl)-1-piperazinyl]-4-quinazolinamine
• 6,7-Dimethoxy-2-[4-(2-propenyl)-1-piperazinyl]-4-quinazolinamine
• 6,7-Dimethoxy-2-[4-(Prop-2-En-1-Yl)Piperazin-1-Yl]Quinazolin-4-Amine
• 7262-00-2
• Quinazoline, 2-(4-allyl-1-piperazinyl)-4-amino-6,7-dimethoxy-
• 6,7-dimethoxy-4-amino-2-(4-allylpiperazin-1-yl)-quinazoline
• Quinazosin

Quinazosin

Controlled Product

CAS: 15793-38-1

Applications Quinazosin is an anti-hypertensive adrenoreceptor antagonist. A useful intermediate for the preparation guanidines and other urea derivatives.
References Greenslade, F. C., et al.: J. Pharm. Sci., 71, (1982), Patil, D. A., et al.: J. Basic Clin. Pharm., 1, 223 (2010)

Formula: C₁₇H₂₃N₅O₂

Color and Shape: Neat

Molecular weight: 329.397

Ref: TR-Q990074

Quinazosin

CAS: 15793-38-1

Quinazosin is an anticancer drug that belongs to the class of kinase inhibitors. It has been shown to induce apoptosis in tumor cells by inhibiting cyclin-dependent kinases. Quinazosin is a potent inhibitor of protein kinase activity and has been used in Chinese herbal medicine for the treatment of cancer. This drug analog has shown promising results in preclinical studies, demonstrating its ability to inhibit the growth and proliferation of various types of cancer cells. Quinazosin is excreted primarily in urine and has a low toxicity profile, making it a potential candidate for future cancer therapy.

Formula: C₁₇H₂₃N₅O₂

Purity: Min. 95%

Molecular weight: 329.4 g/mol

Ref: 3D-QAA79338