CAS 158040-83-6

IFN-γ Antagonist

CAS: 158040-83-6

This peptide derived from the ligand binding site of the human γ-interferon (IFN-γ) receptor is an antagonist of human IFN-γ. It inhibited human IFN-γ-induced expression of HLR/DR antigen on Colo 205 cells with an approximate IC₅₀ of 35 µM. Immobilized peptide specifically bound recombinant human IFN-γ. Tyrosine substitution at residue 121 allowed facile quantification and conjugation of the peptide.

Formula: C₁₁₅H₁₉₄N₃₄O₃₄S

Purity: > 98%

Color and Shape: White Lyophilisate

Molecular weight: 2629.08

Ref: 01-4030819

IFN-γ Antagonist 1

CAS: 158040-83-6

IFN-γ Antagonist 1 (AYCRDGKIGPPKLDIRKEEKQI), an interferon γ (IFN γ) antagonist, effectively inhibits IFN-γ induced HLR/DR antigen expression in Colon 205 cells

Formula: C₁₁₅H₁₉₄N₃₄O₃₄S

Color and Shape: Solid

Molecular weight: 2629.04

Ref: TM-T76637

IFN-γ Antagonist

CAS: 158040-83-6

IFN-gamma antagonist is a regulatory protein that inhibits the activation of IFN-gamma. Activated, or "switched on", IFN-gamma is necessary for the replication of viruses, such as influenza virus. The mechanism of action of this molecule involves binding to and blocking the receptor site for IFN-gamma. This prevents the binding of activated IFN-gamma to its receptor, thereby preventing activation and replication of viruses in cells. IFN-gamma antagonists may also be used to treat cancer in humans as well as other diseases that are regulated by this cytokine.

Formula: C₁₁₅H₁₉₄N₃₄O₃₄S

Purity: Min. 95%

Molecular weight: 2,629.05 g/mol

Ref: 3D-FI108757