Mcl-1 inhibitor 10, identified by its CAS number 1580484-33-8, is a small molecule designed to inhibit the Mcl-1 protein, which is a member of the Bcl-2 family of proteins involved in regulating apoptosis (programmed cell death). This compound is of particular interest in cancer research, as Mcl-1 is often overexpressed in various malignancies, contributing to tumor survival and resistance to chemotherapy. The characteristics of Mcl-1 inhibitor 10 include its ability to selectively bind to the Mcl-1 protein, thereby promoting apoptosis in cancer cells that rely on Mcl-1 for survival. It typically exhibits a favorable pharmacokinetic profile, allowing for effective cellular uptake and bioavailability. Additionally, studies may indicate its efficacy in combination with other therapeutic agents, enhancing the overall treatment response in cancer models. As with many experimental compounds, ongoing research is essential to fully elucidate its mechanism of action, potential side effects, and therapeutic applications in clinical settings.

Mcl-1 inhibitor 10

1580484-33-8: Mcl-1 inhibitor 10, identified by its CAS number 1580484-33-8, is a small molecule designed to inhibit the Mcl-1 protein, which is a member of the Bcl-2 family of proteins involved in regulating apoptosis (programmed cell death). This compound is of particular interest in cancer research, as Mcl-1 is often overexpressed in various malignancies, contributing to tumor survival and resistance to chemotherapy. The characteristics of Mcl-1 inhibitor 10 include its ability to selectively bind to the Mcl-1 protein, thereby promoting apoptosis in cancer cells that rely on Mcl-1 for survival. It typically exhibits a favorable pharmacokinetic profile, allowing for effective cellular uptake and bioavailability. Additionally, studies may indicate its efficacy in combination with other therapeutic agents, enhancing the overall treatment response in cancer models. As with many experimental compounds, ongoing research is essential to fully elucidate its mechanism of action, potential side effects, and therapeutic applications in clinical settings.

Mcl-1 inhibitor10 (compound 43) is a relatively potent MCL-1 inhibitor with an IC50 of 0.67 μM. It interacts with a specific binding site on the MCL-1 protein, disrupting its pro-survival signals and inducing apoptosis in cancer cells. This compound is useful for research on MCL-1-dependent cancers.

CAS 1580484-33-8

Mcl-1 inhibitor 10

Mcl-1 inhibitor 10

Ref: TM-T87994