CAS 158181-47-6

7,13,17,29,33-Pentaoxa-34,35-diazatetracyclo[29.2.1.115,18.06,8]pentatriaconta-1(34),2,4,9,15,18(35),21,23,25,31-decaene-14,30-dione, 12,28-bis[(2S,3E)-2-hydroxy-1,1-dimethyl-3-penten-1-yl]-20-methoxy-, (2Z,4E,6S,8R,9Z,12S,20R,21E,23Z,25Z,28S)-

Description:

The chemical substance known as 7,13,17,29,33-Pentaoxa-34,35-diazatetracyclo[29.2.1.115,18.06,8]pentatriaconta-1(34),2,4,9,15,18(35),21,23,25,31-decaene-14,30-dione, 12,28-bis[(2S,3E)-2-hydroxy-1,1-dimethyl-3-penten-1-yl]-20-methoxy-, (2Z,4E,6S,8R,9Z,12S,20R,21E,23Z,25Z,28S) is a complex organic molecule characterized by its intricate polycyclic structure, which includes multiple rings and functional groups. The presence of multiple oxygen and nitrogen atoms indicates potential for hydrogen bonding and reactivity, while the various stereocenters suggest that it may exhibit specific spatial configurations that could influence its biological activity. The molecule's extensive conjugated system, indicated by the decaene structure, may contribute to its optical properties and stability. Additionally, the presence of hydroxy and methoxy groups suggests potential for solubility in polar solvents and possible interactions with biological systems. Overall, this compound's complexity and functional diversity may make it of interest in fields such as medicinal chemistry or materials science.

Formula: C₄₃H₅₄N₂O₁₀

Synonyms:

• 7,13,17,29,33-Pentaoxa-34,35-diazatetracyclo[29.2.1.115,18.06,8]pentatriaconta-1(34),2,4,9,15,18(35),21,23,25,31-decaene-14,30-dione, 12,28-bis[(2S,3E)-2-hydroxy-1,1-dimethyl-3-penten-1-yl]-20-methoxy-, (2Z,4E,6S,8R,9Z,12S,20R,21E,23Z,25Z,28S)-

Disorazol A

CAS: 158181-47-6

Disorazol A1 is a tubulin inhibitor with antifungal properties. It functions by inhibiting tubulin polymerization and disrupting microtubule formation, thereby blocking mitosis and arresting the cell cycle at the G2/M phase, which induces apoptosis. Disorazol A1 also inhibits L929 mouse fibroblasts with an IC50 value of 3 pm and causes accumulation of p53 protein in the nucleus. Disorazol A1 holds potential for cancer research.

Formula: C₄₃H₅₄N₂O₁₀

Color and Shape: Solid

Molecular weight: 758.896

Ref: TM-TN10381