CAS 158205-05-1

Methanesulfonamide,N-[6-[(2,4-difluorophenyl)thio]-2,3-dihydro-1-oxo-1H-inden-5-yl]-

Description:

Methanesulfonamide, N-[6-[(2,4-difluorophenyl)thio]-2,3-dihydro-1-oxo-1H-inden-5-yl]- is a chemical compound characterized by its complex structure, which includes a methanesulfonamide group and a substituted indene moiety. The presence of the difluorophenyl group indicates that it has potential applications in medicinal chemistry, particularly in the development of pharmaceuticals. This compound may exhibit specific biological activities due to its unique functional groups, which can influence its interactions with biological targets. The sulfonamide functional group is known for its role in various therapeutic agents, often contributing to antibacterial and diuretic properties. Additionally, the presence of fluorine atoms can enhance lipophilicity and metabolic stability, making it a candidate for drug development. Its molecular structure suggests potential for diverse reactivity and interactions, which can be explored in various chemical and biological contexts. As with any chemical substance, safety and handling precautions should be observed, particularly in laboratory settings.

Formula: C₁₆H₁₃F₂NO₃S₂

Synonyms:

• L 745337
• N-[6-[(2,4-Difluorophenyl)thio]-2,3-dihydro-1-oxo-1H-inden-5-yl]methanesulfonamide
• Thioflosulide

Thioflosulide

CAS: 158205-05-1

Thioflosulide

Purity: ≥98%

Molecular weight: 369.41g/mol

Ref: 54-BUP21622

Thioflosulide

CAS: 158205-05-1

Thioflosulide is a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve the symptoms of inflammatory bowel disease. Thioflosulide binds to and inhibits the phospholipase A2 enzyme, which in turn prevents the production of prostaglandin E2. Thioflosulide has been shown to be effective in reducing ulceration and improving quality of life for patients with ulcerative colitis. It also decreases microvessel density, reduces bowel disease severity, and prevents the formation of new blood vessels in the colon. Thioflosulide is an NSAID that blocks cyclooxygenase enzymes and reduces prostaglandin synthesis. It has been shown to be effective against inflammation in animal models.

Formula: C₁₆H₁₃F₂NO₃S₂

Purity: Min. 95%

Molecular weight: 369.4 g/mol

Ref: 3D-IGA20505

Thioflosulide

CAS: 158205-05-1

Thioflosulide (L-745337) is a selective and potent COX2 inhibitor (IC50: 2.3 nM) with anti-inflammatory activity for the study of gastric ulcers.

Formula: C₁₆H₁₃F₂NO₃S₂

Purity: >99.99%

Color and Shape: Solid

Molecular weight: 369.41

Ref: TM-T15687