CAS 15833-07-5

2-BROMOESTRADIOL,(13S,17S)-2-BROMO-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHRENE-3,17-DIOL

Description:

2-Bromoestradiol, also known by its systematic name (13S,17S)-2-bromo-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol, is a synthetic derivative of estradiol, a key estrogen hormone. This compound features a bromine atom substitution at the second carbon position and possesses a complex polycyclic structure characteristic of steroid compounds. It is primarily studied for its potential biological activities, including its effects on estrogen receptors and its role in various biochemical pathways. The presence of hydroxyl groups at the 3 and 17 positions contributes to its hydrophilicity and potential interactions with biological systems. As a brominated derivative, it may exhibit altered pharmacological properties compared to its parent compound, estradiol. The compound is of interest in medicinal chemistry and endocrinology, particularly in research related to hormone signaling, cancer biology, and the development of therapeutic agents targeting estrogen-related conditions. Safety and handling precautions are essential due to its chemical reactivity and potential biological effects.

Formula: C₁₈H₂₃BrO₂

InChI: InChI=1/C18H23BrO2/c1-18-7-6-11-12(14(18)4-5-17(18)21)3-2-10-8-16(20)15(19)9-13(10)11/h8-9,11-12,14,17,20-21H,2-7H2,1H3

SMILES: CC12CCC3C(CCc4cc(c(cc34)Br)O)C1CCC2O

Synonyms:

• Estra-1,3,5(10)-Triene-3,17-Diol, 2-Bromo-
• 2-Bromoestra-1(10),2,4-Triene-3,17-Diol
• 2-Bromo 17β-Estradiol
• 2-BroMo-1,3,5(10)-estratriene-3,17b-diol
• 2-BROMOESTRADIOL,(13S,17S)-2-BROMO-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHRENE-3,17-DIOL
• 2-Bromo 17-beta-Estradiol
• Estra-1,3,5(10)-triene-3,17-diol, 2-bromo-, (17β)-
• 2-bromo-, (17b)-Estra-1,3,5(10)-triene-3,17-diol,2-bromo-

Estra-1,3,5(10)-triene-3,17-diol, 2-bromo-, (17β)-

CAS: 15833-07-5

Formula: C₁₈H₂₃BrO₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 351.2780

Ref: IN-DA001Q57

2-Bromoestradiol

CAS: 15833-07-5

2-Bromoestradiol, an estrogen 2-hydroxylase inhibitor, reduces the irreversible binding of radiolabeled estradiol metabolite(s) to microsomal proteins [1].

Formula: C₁₈H₂₃BrO₂

Color and Shape: Solid

Molecular weight: 351.28

Ref: TM-T84952

2-Bromo 17-β-Estradiol

CAS: 15833-07-5

Formula: C₁₈H₂₃BrO₂

Molecular weight: 351.28

Ref: 4Z-E-0975

2-Bromo 17β-Estradiol

CAS: 15833-07-5

Stability Light Sensitive
Applications 17β-Estradiol (E888000) metabolite. An inhibitor of androstenedione aromatization, which is responsible for the conversion of androgens to estrogens. Agonistic ligands for the estrogen receptor in MCF-7 breast cancer cells.
References Numazawa, M. et al.: J. Steroid. Biochem. Mol. Biol., 96, 51 (2005); Vollmer, G. et al.: J. Seroid. Biochem. Mol. Biol., 39, 359 (1991); Brueggemeier, R. et al.: J. Steroid. Biochem., 21, 709 (1984)

Formula: C₁₈H₂₃BrO₂

Color and Shape: Neat

Molecular weight: 351.28

Ref: TR-B684970