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CAS 158382-37-7

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Canfosfamide

Description:
Canfosfamide, with the CAS number 158382-37-7, is a synthetic compound that belongs to the class of alkylating agents, which are primarily used in chemotherapy for cancer treatment. It is a prodrug of the active form, which exerts its cytotoxic effects by forming DNA cross-links, thereby inhibiting DNA replication and transcription. This mechanism makes it effective against various types of tumors. Canfosfamide is characterized by its ability to selectively target cancer cells while minimizing damage to normal tissues, although side effects can still occur. The compound is typically administered intravenously and has been studied for its efficacy in treating solid tumors, particularly in combination with other chemotherapeutic agents. Its chemical structure includes a phosphoramide moiety, which contributes to its reactivity and biological activity. As with many chemotherapeutic agents, careful monitoring of patient response and potential toxicity is essential during treatment. Research continues to explore its full therapeutic potential and optimize its use in clinical settings.
Formula:C26H40Cl4N5O10PS
InChI:InChI=1S/C26H40Cl4N5O10PS/c27-8-12-34(13-9-28)46(42,35(14-10-29)15-11-30)45-16-17-47(43,44)18-21(32-22(36)7-6-20(31)25(38)39)24(37)33-23(26(40)41)19-4-2-1-3-5-19/h1-5,20-21,23H,6-18,31H2,(H,32,36)(H,33,37)(H,38,39)(H,40,41)/t20-,21-,23+/m0/s1
InChI key:InChIKey=OJLHWPALWODJPQ-QNWVGRARSA-N
SMILES:P(N(CCCl)CCCl)(N(CCCl)CCCl)(OCCS(C[C@@H](C(N[C@@H](C(O)=O)C1=CC=CC=C1)=O)NC(CC[C@@H](C(O)=O)N)=O)(=O)=O)=O
Synonyms:
  • γ-Glutamyl-α-amino-β-[2-ethyl-N,N,N′,N′-tetrakis(2-chloroethyl)phosphorodiamidate]-sulfonyl-propionyl-(R)-(-)-phenylglycine
  • Glycine, N-[3-[[2-[[bis[bis(2-chloroethyl)amino]phosphinyl]oxy]ethyl]sulfonyl]-N-L-γ-glutamyl-L-alanyl]-D-2-phenyl-
  • Canfosfamide
  • Glycine, L-γ-glutamyl-3-[[2-[[bis[bis(2-chloroethyl)amino]phosphinyl]oxy]ethyl]sulfonyl]-L-alanyl-2-phenyl-, (2R)-
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