CAS 158636-96-5

Timolol EP Impurity B (S-Isomer) (Timolol USP Related Compound B (S-Isomer))

CAS: 158636-96-5

Formula: C₁₃H₂₄N₄O₃S

Color and Shape: White To Off-White Solid

Molecular weight: 316.43

Ref: 4Z-T-683

(S)-Isotimolol

Controlled Product

CAS: 158636-96-5

Formula: C₁₃H₂₄N₄O₃S

Color and Shape: Neat

Molecular weight: 316.42

Ref: 86-MM0440.02

(S)-Isotimolol

Controlled Product

CAS: 158636-96-5

Applications An isomer of the antiarrhythmic, antiglaucoma agent Timolol (T443700).
References Marini, R.D. et al.: Anal. Chim. Acta, 531, 131 (2005);

Formula: C₁₃H₂₄N₄O₃S

Color and Shape: White

Molecular weight: 316.42

Ref: TR-I918000

(S)-Isotimolol

CAS: 158636-96-5

(S)-Isotimolol is a ligand for the beta-adrenergic receptor that has been used as a research tool in cell biology and pharmacology. It is an inhibitor of ion channels. (S)-Isotimolol may also be used as a diagnostic aid for determining the presence of peptides or receptors on cells. (S)-Isotimolol is soluble in DMSO, ethanol, and acetone, with a solubility of 1 g/100 mL at 25°C. It is stable to hydrolysis by esterases and other enzymes.
It has been shown to activate the beta-adrenergic receptor at micromolar concentrations. This results in increased calcium influx into the cell, activation of protein kinase A, and increased cyclic adenosine monophosphate (cAMP) levels.
(S)-Isotimolol binds to the alpha-1A subtype of the beta-ad

Formula: C₁₃H₂₄N₄O₃S

Purity: Min. 95%

Molecular weight: 316.42 g/mol

Ref: 3D-IGA63696

(S)-Isotimolol

CAS: 158636-96-5

Formula: C₁₃H₂₄N₄O₃S

Molecular weight: 316.42

Ref: ST-EA-CP-T13015