CAS 158681-13-1

Rimonabant hydrochloride

Description:

Rimonabant hydrochloride is a synthetic cannabinoid and a selective antagonist of the cannabinoid receptor type 1 (CB1). It is primarily known for its application in weight management and obesity treatment, as it works by blocking the effects of endocannabinoids that stimulate appetite. The compound is characterized by its molecular formula, which includes elements such as carbon, hydrogen, nitrogen, and chlorine. Rimonabant hydrochloride is typically presented as a white to off-white crystalline powder, soluble in organic solvents but less so in water. Its pharmacological profile indicates that it may also have effects on mood and anxiety, leading to concerns about potential psychiatric side effects. Due to these adverse effects, Rimonabant was withdrawn from the market in several countries. The substance is classified under various regulatory frameworks, and its use is restricted in many regions. Overall, Rimonabant hydrochloride exemplifies the complex interplay between cannabinoid receptors and metabolic processes, highlighting the challenges in developing safe and effective pharmacotherapies.

Formula: C₂₂H₂₁Cl₃N₄O·ClH

InChI: InChI=1S/C22H21Cl3N4O.ClH/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-9-17(24)13-18(19)25)21(14)15-5-7-16(23)8-6-15;/h5-10,13H,2-4,11-12H2,1H3,(H,27,30);1H

InChI key: InChIKey=REOYOKXLUFHOBV-UHFFFAOYSA-N

SMILES: CC1=C(N(N=C1C(NN2CCCCC2)=O)C3=C(Cl)C=C(Cl)C=C3)C4=CC=C(Cl)C=C4.Cl

Synonyms:

• SR 151716A
• 1H-Pyrazole-3-carboxamide, 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-, hydrochloride (1:1)
• Rimonabant hydrochloride
• SR 141716A
• 1H-Pyrazole-3-carboxamide, 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-, monohydrochloride

1H-Pyrazole-3-carboxamide, 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-, hydrochloride (1:1)

CAS: 158681-13-1

Formula: C₂₂H₂₂Cl₄N₄O

Purity: 98%

Color and Shape: Solid

Molecular weight: 500.2483

Ref: IN-DA001QQL

Rimonabant hydrochloride

CAS: 158681-13-1

Rimonabant hydrochloride (SR 141716A) 是中心大麻素受体 1 的高效选择性反向激动剂， Ki 值为1.8 nM。它也能够抑制分枝杆菌膜蛋白3。

Formula: C₂₂H₂₂Cl₄N₄O

Purity: 98.24% - 99.5%

Color and Shape: Off-White To White Crystalline Powder

Molecular weight: 500.25

Ref: TM-T1519

Rimonabant HCl

CAS: 158681-13-1

Formula: C₂₂H₂₁Cl₃N₄O·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 463.79 36.46

Ref: 4Z-R-261

Rimonabant hydrochloride

CAS: 158681-13-1

Formula: C₂₂H₂₁Cl₃N₄O·HCl

Purity: ≥ 97.0% (dried basis)

Color and Shape: White to off-white crystalline powder

Molecular weight: 500.25

Ref: 7W-GP8358

Rimonabant hydrochloride

Controlled Product

CAS: 158681-13-1

Formula: C₂₂H₂₁Cl₃N₄O·ClH

Color and Shape: White To Off-White

Molecular weight: 500.25

Ref: 04-C16814950

Rimonabant Hydrochloride

CAS: 158681-13-1

Formula: C₂₂H₂₁Cl₃N₄O·HCl

Purity: >95.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 500.25

Ref: 3B-R0293

Rimonabant Hydrochloride

Controlled Product

CAS: 158681-13-1

Applications Rimonabant Hydrochloride is a potent and selective CB1 cannabinoid antagonist used to investigate CB receptor properties (1). Rimonabant Hydrochloride is also an anti-obesity agent (2).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References (1) Carai, M.A.M., et al.: Life Sci., 77, 2339 (2005) (2) Janiak, P., et al.: Kidney Int. 72, 1345 (2007)

Formula: C₂₂H₂₁Cl₃N₄O·ClH

Color and Shape: White To Off-White

Molecular weight: 500.25

Ref: TR-R517800

Rimonabant hydrochloride

Controlled Product

CAS: 158681-13-1

CB1 cannabinoid antagonist, non-CB1/CB2 receptor (GPR55) agonist; anorectic

Formula: C₂₂H₂₂Cl₄N₄O

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 500.25 g/mol

Ref: 3D-FR27735

Rimonabant HCl - Bio-X ™

Controlled Product

CAS: 158681-13-1

Rimonabant is cannabinoid receptor type 1 (CB1) inverse agonist drug. Rimonabant is used to treat obesity by reducing appetite and calorie intake. It lowers the consumption of food, via central and peripheral mechanisms. It also reduces triglyceride and low-density lipoprotein levels (LDLs). This drug has shown to reduce nicotine dependence, potentially by modulating dopaminergic signalling.

Formula: C₂₂H₂₂Cl₄N₄O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 500.25 g/mol

Ref: 3D-BR164347

Rimonabant-13C,d7 Hydrochloride

Controlled Product

CAS: 158681-13-1

Formula: CC₂₁D₇H₁₄Cl₃N₄O·HCl

Color and Shape: Neat

Molecular weight: 508.284

Ref: TR-R517804