CAS 158747-02-5

Frovatriptan

Description:

Frovatriptan is a selective agonist of the serotonin 5-HT_1B and 5-HT_1D receptors, primarily used in the treatment of migraine headaches. It belongs to the triptan class of medications, which are characterized by their ability to alleviate migraine symptoms by constricting cranial blood vessels and inhibiting the release of pro-inflammatory neuropeptides. Frovatriptan is known for its long half-life compared to other triptans, allowing for prolonged therapeutic effects. Its chemical structure includes a sulfonamide group, which contributes to its pharmacological properties. The substance is typically administered orally and is well-absorbed, with peak plasma concentrations occurring within a few hours post-ingestion. Common side effects may include dizziness, fatigue, and nausea, although it is generally well-tolerated. Due to its specific receptor activity, Frovatriptan is particularly effective for treating acute migraine attacks and is often chosen for patients who may benefit from a longer duration of action. As with all medications, it is important for patients to consult healthcare professionals for appropriate use and potential interactions.

Formula: C₁₄H₁₇N₃O

InChI: InChI=1S/C14H17N3O/c1-16-9-3-5-13-11(7-9)10-6-8(14(15)18)2-4-12(10)17-13/h2,4,6,9,16-17H,3,5,7H2,1H3,(H2,15,18)/t9-/m1/s1

InChI key: InChIKey=XPSQPHWEGNHMSK-SECBINFHSA-N

SMILES: C(N)(=O)C=1C=C2C3=C(NC2=CC1)CC[C@@H](NC)C3

Synonyms:

• HSDB 7363
• 1H-Carbazole-6-carboxamide, 2,3,4,9-tetrahydro-3-(methylamino)-, (R)-
• Frovatriptan
• (3R)-2,3,4,9-Tetrahydro-3-(methylamino)-1H-carbazole-6-carboxamide
• 3-(methylamino)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamide
• 1H-Carbazole-6-carboxamide, 2,3,4,9-tetrahydro-3-(methylamino)-, (3R)-
• 1H-Carbazole-6-carboxamide, 2,3,4,9-tetrahydro-3-(methylamino)-, (R)-
• SB 209509
• 1H-Carbazole-6-carboxamide, 2,3,4,9-tetrahydro-3-(methylamino)-, (3R)-
• SB 209509
• (R)-5,6,7,8-Tetrahydro-6-(methylamino)carbazole-3-carboxamide

Frovatriptan

CAS: 158747-02-5

Formula: C₁₄H₁₇N₃O

Molecular weight: 243.31

Ref: 4Z-F-171

(S)-Frovatriptan-d3 Succinate

CAS: 158747-02-5

Formula: C₁₄H₁₄N₃OD₃·C₄H₆O₄

Color and Shape: White To Off-White Solid

Molecular weight: 246.33 118.09

Ref: 4Z-F-1719

Frovatriptan

CAS: 158747-02-5

5-HT1B/1D serotonin receptor agonist; acute treatment for migraine

Formula: C₁₄H₁₇N₃O

Purity: Min. 95%

Molecular weight: 243.3 g/mol

Ref: 3D-FF32713

Frovatriptan

CAS: 158747-02-5

Frovatriptan, potent 5-HT 1B/D agonist, shows high cerebroselectivity and efficacy for migraine with aura.

Formula: C₁₄H₁₇N₃O

Color and Shape: Solid

Molecular weight: 243.3

Ref: TM-T60345