CAS 15876-67-2

Distigmine bromide

Description:

Distigmine bromide is a synthetic quaternary ammonium compound primarily used as a medication to treat myasthenia gravis, a neuromuscular disorder characterized by weakness in the skeletal muscles. It functions as an acetylcholinesterase inhibitor, enhancing the action of acetylcholine at neuromuscular junctions, thereby improving muscle contraction and strength. The substance appears as a white to off-white crystalline powder and is soluble in water, which facilitates its administration. Its chemical structure includes two quaternary ammonium groups, contributing to its pharmacological activity. Distigmine bromide is typically administered orally or via injection, and its effects can be observed relatively quickly, making it effective for managing symptoms of muscle weakness. However, it may also cause side effects such as gastrointestinal disturbances, increased salivation, and muscle cramps. As with any medication, careful dosage and monitoring are essential to minimize adverse effects and ensure therapeutic efficacy.

Formula: C₂₂H₃₂N₄O₄·2Br

InChI: InChI=1/C22H32N4O4.2BrH/c1-23-13-9-11-19(17-23)29-21(27)25(3)15-7-5-6-8-16-26(4)22(28)30-20-12-10-14-24(2)18-20;;/h9-14,17-18H,5-8,15-16H2,1-4H3;2*1H/q+2;;/p-2

InChI key: InChIKey=GJHSNEVFXQVOHR-UHFFFAOYSA-L

SMILES: O(C(N(CCCCCCN(C(OC1=C[N+](C)=CC=C1)=O)C)C)=O)C2=C[N+](C)=CC=C2.[Br-]

Synonyms:

• 3,3'-{Hexane-1,6-Diylbis[(Methylcarbamoyl)Oxy]}Bis(1-Methylpyridinium) Dibromide
• 3-Hydroxy-1-methylpyridinium bromide, hexamethylenebis[methylcarbamate]
• Bc 51
• Distigmine Br
• Distigmine dibromide
• Hexamarium
• Hexamarium bromide
• N,N′-Hexamethylenebis(3-N-methylcarbamoxy-1-methylpyridine)dibromide
• Pyridinium, 3,3′-[1,6-hexanediylbis[(methylimino)carbonyl]oxy]bis[1-methyl-, bromide (1:2)
• Pyridinium, 3,3′-[1,6-hexanediylbis[(methylimino)carbonyl]oxy]bis[1-methyl-, dibromide
• Pyridinium, 3-hydroxy-1-methyl-, bromide, hexamethylenebis[methylcarbamate] (2:1)
• Ubretid
• Ubritil
• BC51
• (1-methylpyridin-1-ium-3-yl) N-methyl-N-[6-[methyl-(1-methylpyridin-1-ium-3-yl)oxycarbonylamino]hexyl]carbamate dibromide
• 3-Hydroxy-1-methylpyridinium
• (1-methylpyridin-1-ium-3-yl) N-methyl-N-[6-[methyl-(1-methylpyridin-1-ium-3-yl)oxycarbonyl-amino]hexyl]carbamate dibromide
• distigmine bromide
• N-methyl-N-[6-[methyl-(1-methylpyridin-1-ium-3-yl)oxycarbonyl-amino]hexyl]carbamic acid (1-methylpyridin-1-ium-3-yl) ester dibromide
• 3,3'-(((Hexane-1,6-diylbis(methylazanediyl))bis(carbonyl))bis(oxy))bis(1-methylpyridin-1-ium) bromide
• Denispan
• Ubtec
• Distigmine

Distigmine Bromide

CAS: 15876-67-2

Color and Shape: Neat

Ref: 61-FOR1167.00

Pyridinium, 3,3'-[1,6-hexanediylbis[(methylimino)carbonyl]oxy]bis[1-methyl-, bromide (1:2)

CAS: 15876-67-2

Formula: C₂₂H₃₂Br₂N₄O₄

Purity: 99%

Color and Shape: Solid

Molecular weight: 576.3219

Ref: IN-DA001QU9

Distigmine Bromide

CAS: 15876-67-2

Formula: C₂₂H₃₂N₄O₄·2Br

Color and Shape: White To Off-White Solid

Molecular weight: 416.52 2x79.90

Ref: 4Z-D-137001

Distigmine Bromide-d6

Controlled Product

CAS: 15876-67-2

Applications Distigmine Bromide-d6 is the isotope labelled analog of Distigmine Bromide (D493530); a cholinesterase inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sugaya, K.,e t. al.: Int. J. Urology, 19, 480 (2012)

Formula: C₂₂H₂₆D₆N₄O₄•2(Br)

Color and Shape: Neat

Molecular weight: 582.36

Ref: TR-D493532

Distigmine Bromide

Controlled Product

CAS: 15876-67-2

Stability Hygroscopic, Temperature Sensitive
Applications Distigmine Bromide is a cholinesterase inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sugaya, K.,e t. al.: Int. J. Urology, 19, 480 (2012)

Formula: C₂₂H₃₂N₄O₄·2Br

Color and Shape: Neat

Molecular weight: 576.32

Ref: TR-D493530

Distigmine bromide

CAS: 15876-67-2

Distigmine bromide is a cholinergic agent that can be used to treat the symptoms of urinary incontinence. It is also used to treat underactive bladders and the symptoms associated with it. Distigmine bromide belongs to pharmacological agents and is an acetylcholinesterase inhibitor. This drug is administered by mouth, and its effects are long-lasting. It can be used for the treatment of psychotic disorders as well as for diagnosis of bladder disease.

Formula: C₂₂H₃₂N₄O₄•(Br)₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 576.32 g/mol

Ref: 3D-FD42999

Distigmine Bromide

CAS: 15876-67-2

Distigmine Bromide is an acetylcholinesterase inhibitor. It is used for the treatment of underactive neurogenic bladder and myasthenia gravis.

Formula: C₂₂H₃₂BrN₄O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 496.42

Ref: TM-T7825