CAS 158876-82-5

Rupatadine

Description:

Rupatadine is a second-generation antihistamine primarily used for the treatment of allergic conditions such as allergic rhinitis and urticaria. It functions as a selective antagonist of the H1 histamine receptor, which helps alleviate symptoms associated with allergic reactions, such as sneezing, itching, and runny nose. Additionally, Rupatadine exhibits anti-inflammatory properties by inhibiting the release of pro-inflammatory mediators. The substance is characterized by its relatively low sedative effects compared to first-generation antihistamines, making it suitable for long-term use without significant drowsiness. Rupatadine is typically administered orally and has a favorable pharmacokinetic profile, including good absorption and a moderate half-life, allowing for once-daily dosing. Its chemical structure includes a piperidine ring, contributing to its pharmacological activity. Overall, Rupatadine is recognized for its efficacy in managing allergic symptoms while minimizing sedation, making it a valuable option in allergy treatment regimens.

Formula: C₃₀H₃₀ClN₃O₄

InChI: InChI=1/C26H26ClN3.C4H4O4/c1-18-13-19(16-28-15-18)17-30-11-8-20(9-12-30)25-24-7-6-23(27)14-22(24)5-4-21-3-2-10-29-26(21)25;5-3(6)1-2-4(7)8/h2-3,6-7,10,13-16H,4-5,8-9,11-12,17H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+

InChI key: InChIKey=WUZYKBABMWJHDL-UHFFFAOYSA-N

SMILES: ClC=1C=C2C(C(C=3C(CC2)=CC=CN3)=C4CCN(CC=5C=C(C)C=NC5)CC4)=CC1

Synonyms:

• 5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 8-chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)methyl]-4-piperidinylidene]-
• 8-Chloro-6,11-Dihydro-11-[1-[(5-Methyl-3-Pyridyl)Methyl]-4-Piperidylidene]-5H-Benzo[5,6]Cyclohepta[1,2-B]Pyridine
• 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)methyl]-4-piperidinylidene]-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
• 8-chloro-11-{1-[(5-methylpyridin-3-yl)methyl]piperidin-4-ylidene}-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine (2E)-but-2-enedioate
• Alergoliber
• Pafinur
• Rinialer
• Rupafin
• Rupax
• Rupatadine
• RUPATADINE FREE BASE
• RUPATADINEFUMARATE(FORR&DONLY)
• Rupafi
• 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)methyl]-4-piperidinylidene]-5H-benzo[5,6]cyclohepta[1,2-β]pyridine (2E)-2-Butenedioate

5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 8-chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)methyl]-4-piperidinylidene]-

CAS: 158876-82-5

Formula: C₂₆H₂₆ClN₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 415.9577

Ref: IN-DA001QYV

8-Chloro-11-(1-((5-Methylpyridin-3-Yl)Methyl)Piperidin-4-Ylidene)-6,11-Dihydro-5H-Benzo[5,6]Cyclohepta[1,2-B]Pyridine

CAS: 158876-82-5

8-Chloro-11-(1-((5-Methylpyridin-3-Yl)Methyl)Piperidin-4-Ylidene)-6,11-Dihydro-5H-Benzo[5,6]Cyclohepta[1,2-B]Pyridine

Purity: 98%

Molecular weight: 415.96g/mol

Ref: 54-OR1025672

Rupatadine

CAS: 158876-82-5

Formula: C₂₆H₂₆ClN₃

Color and Shape: Off-White Solid

Molecular weight: 415.97

Ref: 4Z-R-423

Rupatadine

CAS: 158876-82-5

Rupatadine (UR-12592, rupatadine) is a potent and orally available dual antagonist of PAF and histamine H1 receptors ,allergic and anti-inflammatory.

Formula: C₂₆H₂₆ClN₃

Purity: 99.87%

Color and Shape: Solid

Molecular weight: 415.96

Ref: TM-T36618

Rupatadine

Controlled Product

CAS: 158876-82-5

Applications Rupatadine is an intermediate in the synthesis of Rupatadine (5-Methyl-3-pyridinyl)methyl)pyridinium Chloride (M326740). (5-Methy-3-pyridinyl)methyl-Rupatadine is an impurity of Rupatadine (R701650), a dual antagonist of histamine H1 and platelet-activating factor receptors
References Merlos, M., et al.: J. Pharmacol. Exp. Ther., 280, 114 (1997), Guadano, E.M., et al.: Allergy, 59, 766 (2004),

Formula: C₂₆H₂₆ClN₃

Color and Shape: Neat

Molecular weight: 415.965

Ref: TR-R701653

8-Chloro-11-(1-((5-methylpyridin-3-yl)methyl)piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

CAS: 158876-82-5

Rupatadine is a drug that has been shown to have antihistamine and anticholinergic properties. It is used for the treatment of allergic rhinitis, chronic idiopathic urticaria, and pruritus. Rupatadine has also been investigated for its potential use in the treatment of solid tumours. Rupatadine belongs to a class of drugs called histamine H1 receptor antagonists. In experimental models, it has been shown to inhibit the growth of certain types of cancer cells by blocking the activity of histamine receptors on cell membranes and inhibiting protein synthesis. The drug also inhibits cardiac potassium channels, which may lead to cardiac effects such as arrhythmias or heart block. Rupatadine fumarate is metabolized into rupatadine (RUP) by esterases and oxidized by cytochrome P450 enzymes or conjugated with glucuronic acid. This active form binds to proteins

Formula: C₂₆H₂₆ClN₃

Purity: Min. 95%

Molecular weight: 415.97 g/mol

Ref: 3D-IGA87682