CAS 15888-38-7
:5′-Acetyl-2′,3′-isopropylideneadenosine
Description:
5′-Acetyl-2′,3′-isopropylideneadenosine is a modified nucleoside that features an adenosine backbone with specific chemical modifications. This compound is characterized by the presence of an acetyl group at the 5' position and an isopropylidene group at the 2' and 3' positions of the ribose sugar. These modifications enhance its stability and influence its biological activity, making it of interest in biochemical and pharmaceutical research. The isopropylidene group provides steric hindrance, which can affect the compound's interactions with enzymes and receptors. Additionally, the acetyl group can influence solubility and permeability, important factors for drug development. This nucleoside derivative is often studied for its potential roles in cellular processes, including its effects on nucleic acid metabolism and signaling pathways. Its unique structural features make it a valuable tool in the study of nucleoside analogs and their applications in therapeutic contexts.
Formula:C15H19N5O5
InChI:InChI=1/C15H19N5O5/c1-7(21)22-4-8-10-11(25-15(2,3)24-10)14(23-8)20-6-19-9-12(16)17-5-18-13(9)20/h5-6,8,10-11,14H,4H2,1-3H3,(H2,16,17,18)
InChI key:InChIKey=AGPPMENETHBDES-IDTAVKCVSA-N
SMILES:C(OC(C)=O)[C@H]1O[C@H]([C@]2([C@@]1(OC(C)(C)O2)[H])[H])N3C=4C(N=C3)=C(N)N=CN4
Synonyms:- 2′,3′-O-Isopropylidene-5′-O-acetyladenosine
- 5'-O-acetyl-2',3'-O-(1-methylethylidene)adenosine
- 5-Acetyl-2,3-Isopropylenadenosine
- 5′-Acetyl-2′,3′-isopropylideneadenosine
- 5′-O-Acetyl-2′,3′-O-isopropylideneadenosine
- 9-[5-O-acetyl-2,3-O-(1-methylethylidene)pentofuranosyl]-9H-purin-6-amine
- Adenosine, 2′,3′-O-(1-methylethylidene)-, 5′-acetate
- Adenosine, 2′,3′-O-isopropylidene-, 5′-acetate
- Furo[3,4-d]-1,3-dioxole, adenosine deriv.
- NSC 90373
- 5'-O-Acetyl-2',3'-O-isopropylideneadenosine
- Adenosine, 2',3'-O-(1-methylethylidene)-, 5'-acetate
- 2',3'-ISOPROPYLIDENEADENOSINE-5'-MONOACETATE
- 1-((1R,2R,4R,5R)-4-(6-Amino-9H-purin-9-yl)-1,5-dihydroxy-6,6-dimethyl-3-oxabicyclo[3.1.0]hexan-2-yl)-1-hydroxypropan-2-one
- 2',3'-O-ISOPROPYLIDENE-5'-O-ACETYLADENOSINE
- 5'-ACETYL-2',3'-ISOPROPYLIDENEADENOSINE
- 2'-O,3'-O-(1-Methylethylidene)adenosine 5'-acetate
- 2'-O,3'-O-Isopropylideneadenosine 5'-acetate
- 2′,3′-O-Isopropylideneadenosine 5′-monoacetate
- 2',3'-O-(1-Methylethylidene)adenosine 5'-Acetate
- 5'-O-Acetyl-2',3'-O-isopropylidene-D-adenosine
- acetic acid [(3aR,4R,6aR)-4-(6-aminopurin-9-yl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methyl ester
- 2'-O,3'-O-Isopropylidene-5'-O-acetyladenosine
- See more synonyms
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Found 5 products.
Adenosine, 2',3'-O-(1-methylethylidene)-, 5'-acetate
CAS:Formula:C15H19N5O5Purity:95%Color and Shape:SolidMolecular weight:349.34195'-O-Acetyl-2',3'-O-isopropylideneadenosine
CAS:5'-O-Acetyl-2',3'-O-isopropylideneadenosinePurity:95%Molecular weight:349.35g/mol5’-Acetyl-2’,3’-isopropylidene Adenosine
CAS:Controlled ProductFormula:C15H19N5O5Color and Shape:NeatMolecular weight:349.345'-O-Acetyl-2',3'-O-isopropylideneadenosine
CAS:<p>5'-O-Acetyl-2',3'-O-isopropylideneadenosine is an anti-leishmanial agent that is synthesized from 2,3-O-isopropylideneadenosine by acetylating the 5' hydroxyl group. It was found to be more potent than the parent compound and other related compounds in inhibiting Leishmania amazonensis promastigotes. The proposed mechanism of action of 5'-O-acetyl-2',3'-O-isopropylideneadenosine involves hydrogen bonding with the guanosine moiety of DNA and inhibition of RNA synthesis. This drug also has an effect on carbonyl oxygens and resonances, which are observed in the nmr spectra. The synthetic scheme for this drug starts with uridine, which is converted to cytidine by reacting it with sodium cyanide in aqueous solution at 0°C. Cytidine</p>Formula:C15H19N5O5Purity:Min. 95%Color and Shape:PowderMolecular weight:349.34 g/mol
