CAS 158913-22-5

Succinimidyl 6-[3-(2-Pyridyldithio)propionamido]hexanoate

Description:

Succinimidyl 6-[3-(2-Pyridyldithio)propionamido]hexanoate, with CAS number 158913-22-5, is a chemical compound commonly used in bioconjugation and protein labeling applications. It features a succinimidyl ester functional group, which is known for its ability to react with amines, facilitating the conjugation of biomolecules. The presence of a pyridyldithio group allows for selective reduction and cleavage reactions, making it useful in creating disulfide linkages in proteins or peptides. This compound typically exhibits good solubility in organic solvents and is stable under standard laboratory conditions. Its structure enables it to serve as a versatile linker in the development of bioconjugates, such as antibody-drug conjugates or targeted delivery systems. Additionally, the pyridine moiety can participate in further chemical reactions, enhancing its utility in various biochemical applications. Overall, this compound is valuable in research and therapeutic contexts where precise biomolecule modification is required.

Formula: C₁₈H₂₃N₃O₅S₂

InChI: InChI=1/C18H23N3O5S2/c22-14(10-13-27-28-15-6-3-5-12-20-15)19-11-4-1-2-7-18(25)26-21-16(23)8-9-17(21)24/h3,5-6,12H,1-2,4,7-11,13H2,(H,19,22)

SMILES: C(CCC(=O)ON1C(=O)CCC1=O)CCN=C(CCSSc1ccccn1)O

Synonyms:

• N-succinimidyl 6-(3-(2-pyridyldithio)propionamido)hexanoate
• N-{6-[(2,5-dioxopyrrolidin-1-yl)oxy]-6-oxohexyl}-3-(pyridin-2-yldisulfanyl)propanamide

Hexanoic acid, 6-[[1-oxo-3-(2-pyridinyldithio)propyl]amino]-, 2,5-dioxo-1-pyrrolidinyl ester

CAS: 158913-22-5

Formula: C₁₈H₂₃N₃O₅S₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 425.5223

Ref: IN-DA001R0K

SPDP-C6-NHS ester

CAS: 158913-22-5

SPDP-C6-NHS ester is a linker for PROTAC synthesis, joining an E3 ligase ligand to a target ligand, enabling selective protein degradation by UPS.

Formula: C₁₈H₂₃N₃O₅S₂

Purity: 98.96%

Color and Shape: Solid

Molecular weight: 425.52

Ref: TM-T16915

Succinimidyl 6-[3-(2-pyridylthio)propionamidohexanoate

CAS: 158913-22-5

Succinimidyl 6-[3-(2-pyridylthio)propionamidohexanoate

Color and Shape: White Solid

Molecular weight: 425.52g/mol

Ref: 54-BICL208

SPDP-C6-NHS ester

CAS: 158913-22-5

Purity: 97%

Molecular weight: 425.52

Ref: 10-F986885

Succinimidyl 6-[3-(2-pyridyldithio)propionamido]hexanoate

CAS: 158913-22-5

Succinimidyl 6-[3-(2-pyridyldithio)propionamido]hexanoate is an amide that is used as a model system to study protein synthesis. It binds to lysine residues on the surface of cells and stimulates the production of proteins by binding to the EGF receptor. This product has been shown to enhance oxygenated growth factor, which may be due to its ability to inhibit PDGF receptors. Succinimidyl 6-[3-(2-pyridyldithio)propionamido]hexanoate also enhances cell growth and proliferation in different model systems, including monoclonal antibody production.

Formula: C₁₈H₂₃N₃O₅S₂

Purity: Min. 95%

Molecular weight: 425.52 g/mol

Ref: 3D-FS27900