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CAS 158922-07-7

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FMOC-NIP-OH

Description:
FMOC-NIP-OH, or 9-fluorenylmethoxycarbonyl-N-isopropyl-2-aminoethanol, is a chemical compound commonly used in peptide synthesis and as a protecting group for amino acids. It features a fluorenylmethoxycarbonyl (FMOC) group, which is a popular protecting group due to its stability under basic conditions and ease of removal under mild acidic conditions. The presence of the isopropyl group contributes to its steric hindrance, making it useful in selective reactions. FMOC-NIP-OH is typically utilized in solid-phase peptide synthesis, where it helps to protect the amino group during the coupling process. The compound is characterized by its relatively high molecular weight and specific functional groups that influence its reactivity and solubility. Its CAS number, 158922-07-7, allows for easy identification in chemical databases. Overall, FMOC-NIP-OH is valued in synthetic organic chemistry for its effectiveness in facilitating the formation of peptide bonds while providing protection to sensitive functional groups.
Formula:C21H21NO4
InChI:InChI=1/C21H21NO4/c23-20(24)14-6-5-11-22(12-14)21(25)26-13-19-17-9-3-1-7-15(17)16-8-2-4-10-18(16)19/h1-4,7-10,14,19H,5-6,11-13H2,(H,23,24)
SMILES:c1ccc2c(c1)c1ccccc1C2COC(=O)N1CCCC(C1)C(=O)O
Synonyms:
  • (R,S)-Nipecotic Acid
  • (Rs)-N-Fmoc-Piperidine-3-Carboxylic Acid
  • (Rs)-N-(-Fluorenylmethyloxycarbonyl)-Piperidine-3-Carboxylic Acid
  • (R,S)-Fmoc-Nipecotic Acid
  • (Rs)-N-(9-Fluorenylmethyloxycarbonyl)-Nipecotic Acid
  • Rarechem Em Wb 0155
  • N-(9-Fluorenylmethoxycarbonyl)-Dl-3-Piperidinecarboxylic Acid
  • N-(9-Fluorenylmethoxycarbonyl)-Dl-Nipecotic Acid
  • 1-[(9H-fluoren-9-ylmethoxy)carbonyl]piperidine-3-carboxylic acid
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