CAS 158930-09-7

Frovatriptan Succinate

Description:

Frovatriptan succinate is a selective serotonin receptor agonist, primarily used in the treatment of migraine headaches. It acts on the 5-HT_1B and 5-HT_1D serotonin receptors, leading to vasoconstriction of cranial blood vessels and inhibition of pro-inflammatory neuropeptide release. This compound is characterized by its relatively long half-life compared to other triptans, allowing for sustained relief from migraine symptoms. Frovatriptan is typically administered orally and is known for its favorable side effect profile, which includes a lower incidence of rebound headaches. The succinate salt form enhances its solubility and stability, making it suitable for pharmaceutical formulations. In terms of physical properties, it is a white to off-white crystalline powder, and its solubility varies in different solvents. As with any medication, it is essential to consider contraindications and potential interactions with other drugs. Overall, frovatriptan succinate represents an important option in the acute management of migraines, particularly for patients who may benefit from its longer duration of action.

Formula: C₁₈H₂₃N₃O₅

InChI: InChI=1/C14H17N3O.C4H6O4/c1-16-9-3-5-13-11(7-9)10-6-8(14(15)18)2-4-12(10)17-13;5-3(6)1-2-4(7)8/h2,4,6,9,16-17H,3,5,7H2,1H3,(H2,15,18);1-2H2,(H,5,6)(H,7,8)/t9-;/m1./s1

SMILES: CN[C@@H]1CCc2c(C1)c1cc(ccc1[nH]2)C(=N)O.C(CC(=O)O)C(=O)O

Synonyms:

• SB-209509ax
• Vml 251
• 1H-Carbazole-6-carboxamide, 2,3,4,9-tetrahydro-3-(methylamino)-, (3R)-, butanedioate (1:1)
• 1H-Carbazole-6-carboxamide, 2,3,4,9-tetrahydro-3-(methylamino)-, (R)-, butanedioate (1:1)
• Butanedioic acid, compd. with (3R)-2,3,4,9-tetrahydro-3-(methylamino)-1H-carbazole-6-carboxamide (1:1)
• (3R)-3-(methylamino)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamide butanedioate (1:1)

Butanedioic acid, compd. with (3R)-2,3,4,9-tetrahydro-3-(methylamino)-1H-carbazole-6-carboxamide (1:1)

CAS: 158930-09-7

Formula: C₁₈H₂₃N₃O₅

Purity: 97%

Color and Shape: Solid

Molecular weight: 361.3923

Ref: IN-DA001R0C

Licarin A

CAS: 158930-09-7

Licarin A

Purity: ≥98%

Molecular weight: 326.39g/mol

Ref: 54-BUP20409

Frovatriptan-d3 Succinate

CAS: 158930-09-7

Formula: C₁₄H₁₄D₃N₃O·C₄H₆O₄

Color and Shape: White To Off-White Solid

Molecular weight: 246.33 118.09

Ref: 4Z-F-173

Frovatriptan Succinate

CAS: 158930-09-7

Formula: C₁₄H₁₇N₃O·C₄H₆O₄

Color and Shape: White To Off-White Solid

Molecular weight: 243.31 118.09

Ref: 4Z-F-175

Frovatriptan Succinate

CAS: 158930-09-7

Frovatriptan Succinate is a synthetic triptan with 5-HT1B/1D receptors agonist activity. It is indicated for the acute treatment of migraine.

Formula: C₁₈H₂₅N₃O₆

Color and Shape: Solid

Molecular weight: 379.41

Ref: TM-T21407

Frovatriptan succinate

CAS: 158930-09-7

5-HT1B/1D serotonin receptor agonist; acute treatment for migraine

Formula: C₁₄H₁₇N₃O•C₄H₆O₄

Purity: Min. 95%

Color and Shape: White/Off-White Solid

Molecular weight: 361.4 g/mol

Ref: 3D-FF61506