CAS 158930-17-7

Frova

Description:

Frova, with the CAS number 158930-17-7, is the brand name for the active pharmaceutical ingredient frovatriptan, which belongs to the triptan class of medications. It is primarily used for the acute treatment of migraine attacks. Frovatriptan functions as a selective agonist for serotonin receptors, specifically the 5-HT_1B and 5-HT_1D subtypes, which are involved in vasoconstriction and the modulation of neurotransmitter release. This mechanism helps alleviate migraine symptoms by reducing inflammation and constricting dilated blood vessels in the brain. Frovatriptan is characterized by its relatively long half-life compared to other triptans, allowing for prolonged efficacy in migraine relief. It is typically administered orally and is well-tolerated, with common side effects including dizziness, fatigue, and nausea. As with other triptans, it is contraindicated in patients with certain cardiovascular conditions due to the potential for vasoconstriction. Overall, frovatriptan is an effective option for managing acute migraine episodes.

Formula: C₁₈H₂₅N₃O₆

InChI: InChI=1/C14H17N3O.C4H6O4.H2O/c1-16-9-3-5-13-11(7-9)10-6-8(14(15)18)2-4-12(10)17-13;5-3(6)1-2-4(7)8;/h2,4,6,9,16-17H,3,5,7H2,1H3,(H2,15,18);1-2H2,(H,5,6)(H,7,8);1H2

SMILES: CNC1CCc2c(C1)c1cc(ccc1[nH]2)C(=N)O.C(CC(=O)O)C(=O)O.O

Synonyms:

• (3R)-2,3,4,9-Tetrahydro-3-(methylamino)-1H-carbazole-6-carboxamide Butanedioic Acid Monohydrate
• Frovatriptan Succinate Monohydrate
• Frovelan
• Migard
• (3R)-3-(methylamino)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamide
• Frovatriptan succinate hydrate
• 1H-Carbazole-6-carboxamide, 2,3,4,9-tetrahydro-3-(methylamino)-, (R)-, butanedioate (1:1), monohydrate
• Miguard
• Frova
• Butanedioic acid, compd. with (R)-2,3,4,9-tetrahydro-3-(methylamino)-1H-carbazole-6-carboxamide (1:1), monohydrate
• Frovatriptan succinate [usan]

Frovatriptan Succinate

CAS: 158930-17-7

Analgesics, antipyretics and non-hormonal anti-inflammatory agents

Formula: C₁₄H₁₇N₃O·C₄H₆O₄·H₂O

Color and Shape: White Off-White Powder

Molecular weight: 379.17434

Ref: 45-1286413

Frovatriptan succinate hydrate

CAS: 158930-17-7

Frovatriptan treats all migraine types, nausea, vomiting, light/sound sensitivity, and prevents menstrual migraines; it targets 5-HT1B/D and 5-HT7 receptors.

Formula: C₁₈H₂₅N₃O₆

Purity: 99.66%

Color and Shape: Solid

Molecular weight: 379.41

Ref: TM-T11326

Frovatriptan (succinate hydrate)

CAS: 158930-17-7

Formula: C₁₈H₂₅N₃O₆

Purity: 99%

Color and Shape: Solid

Molecular weight: 379.4076

Ref: IN-DA001R0A

Frovatriptan succinate hydrate

CAS: 158930-17-7

Frovatriptan succinate hydrate

Purity: ≥98%

Molecular weight: 379.41g/mol

Ref: 54-BUP09657

Crotamiton Impurity 1

CAS: 158930-17-7

Formula: C₁₁H₁₃NO

Molecular weight: 175.23

Ref: 4Z-C-308004

Frovatriptan Succinate Monohydrate

Controlled Product

CAS: 158930-17-7

Formula: C₁₄H₁₇N₃O·C₄H₆O₄·H₂O

Color and Shape: Neat

Molecular weight: 379.41

Ref: TR-F768500

rac Frovatriptan-d3 Succinate Monohydrate (2:1:1)

Controlled Product

CAS: 158930-14-4, 158930-17-7

Formula: C₁₄D₃H₁₄N₃O·C₄H₆O₄·H₂O

Color and Shape: Neat

Molecular weight: 382.426

Ref: TR-F768502

Frovatriptan succinate monohydrate

CAS: 158930-17-7

Frovatriptan succinate is a drug that belongs to the class of anti-migraine drugs. It is a selective serotonin receptor agonist and inhibits the release of neurotransmitters from nerve endings in the brain. Frovatriptan succinate has been shown to be effective for migraine, with significant relief starting about 30 minutes after taking the drug. It has been shown to be well tolerated and effective in patients with hepatic impairment, although it should not be used in patients with severe liver disease. Frovatriptan succinate is marketed as a controlled-release preparation that can be taken once per day. The drug binds to plasma proteins and has a short half-life (approximately 2 hours). It is metabolized by hepatic cytochrome P450 enzymes and excreted primarily through the kidneys. Frovatriptan succinate may also interact with nonsteroidal anti-inflammatory drugs, such as aspirin or ibuprofen, which could increase the risk

Formula: C₁₄H₁₇N₃O•C₄H₆O₄•H₂O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 379.41 g/mol

Ref: 3D-IGA93017