CAS 158930-18-8
:(S)-Frovatriptan
Description:
(S)-Frovatriptan is a selective agonist of the serotonin 5-HT_1B and 5-HT_1D receptors, primarily used in the treatment of migraine headaches. It belongs to the triptan class of medications, which are characterized by their ability to alleviate migraine symptoms by constricting cranial blood vessels and inhibiting the release of pro-inflammatory neuropeptides. The substance has a chiral center, making its (S)-enantiomer the active form, which contributes to its pharmacological efficacy. Frovatriptan is known for its relatively long half-life compared to other triptans, allowing for sustained relief from migraine symptoms. It is typically administered orally and is well-absorbed in the gastrointestinal tract. Common side effects may include dizziness, fatigue, and sensations of tingling or warmth. As with other triptans, caution is advised in patients with cardiovascular conditions due to potential vasoconstrictive effects. Overall, (S)-Frovatriptan is a valuable option in migraine management, particularly for patients who may benefit from its longer duration of action.
Formula:C14H17N3O
InChI:InChI=1S/C14H17N3O/c1-16-9-3-5-13-11(7-9)10-6-8(14(15)18)2-4-12(10)17-13/h2,4,6,9,16-17H,3,5,7H2,1H3,(H2,15,18)/t9-/m0/s1
InChI key:InChIKey=XPSQPHWEGNHMSK-VIFPVBQESA-N
SMILES:C(N)(=O)C=1C=C2C3=C(NC2=CC1)CC[C@H](NC)C3
Synonyms:- (3S)-2,3,4,9-Tetrahydro-3-(methylamino)-1H-carbazole-6-carboxamide
- (S)-Frovatriptan
- 1H-Carbazole-6-carboxamide, 2,3,4,9-tetrahydro-3-(methylamino)-, (3S)-
- 1H-Carbazole-6-carboxamide, 2,3,4,9-tetrahydro-3-(methylamino)-, (S)-
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Found 3 products.
1H-Carbazole-6-carboxamide, 2,3,4,9-tetrahydro-3-(methylamino)-, (3S)-
CAS:Formula:C14H17N3OColor and Shape:SolidMolecular weight:243.3043ent-Frovatriptan
CAS:Controlled ProductApplications ent-Frovatriptan is a serotonin 5-HT1B/1D receptor agonist and used as a triptan drug for treating migraine headaches (1,2,3). ent-Frovatriptan causes vasoconstriction of arteries and veins that supply blood to the head.
References (1) Parsons, A.A., et al.: J. Cardiovasc. Pharmacol., 30, 136 (1997)(2) Siow, C.H., et al.: Cephalalgia, 24, 1045 (2004)(3) Poolsup, N., et al.: J. Clin. Pharm. Ther., 30, 521 (2005)Formula:C14H17N3OColor and Shape:NeatMolecular weight:243.3
