Propargyl-PEG5-amine is a chemical compound characterized by its structure, which includes a propargyl group and a polyethylene glycol (PEG) moiety with five ethylene glycol units, terminated by an amine functional group. This compound is often utilized in bioconjugation and drug delivery applications due to its hydrophilic PEG segment, which enhances solubility and biocompatibility. The propargyl group allows for click chemistry reactions, particularly with azides, facilitating the formation of stable linkages in various biochemical contexts. The amine group can serve as a reactive site for further modifications or conjugations, making it versatile for synthesizing complex biomolecules. Additionally, the presence of the PEG chain can reduce protein adsorption and improve pharmacokinetics, making Propargyl-PEG5-amine a valuable tool in pharmaceutical and biomedical research. Its properties, such as molecular weight and reactivity, can be tailored by modifying the PEG length or the functional groups attached, allowing for customization in various applications.

Propargyl-PEG5-amine is a propargyl linker that is commonly used as a Click Chemistry reagent for copper-catalyzed reactions with azides. The amine moiety reacts with carboxylic acids, activated NHS esters and other carbonyl compounds. The PEG spacer helps improve the water solubility of the molecule in aqueous media.

Propargyl-PEG5-amine

1589522-46-2: Propargyl-PEG5-amine is a chemical compound characterized by its structure, which includes a propargyl group and a polyethylene glycol (PEG) moiety with five ethylene glycol units, terminated by an amine functional group. This compound is often utilized in bioconjugation and drug delivery applications due to its hydrophilic PEG segment, which enhances solubility and biocompatibility. The propargyl group allows for click chemistry reactions, particularly with azides, facilitating the formation of stable linkages in various biochemical contexts. The amine group can serve as a reactive site for further modifications or conjugations, making it versatile for synthesizing complex biomolecules. Additionally, the presence of the PEG chain can reduce protein adsorption and improve pharmacokinetics, making Propargyl-PEG5-amine a valuable tool in pharmaceutical and biomedical research. Its properties, such as molecular weight and reactivity, can be tailored by modifying the PEG length or the functional groups attached, allowing for customization in various applications.

<p>Propargyl-PEG5-amine: Non-cleavable PEG linker for ADC and PROTAC synthesis.</p>

CAS 1589522-46-2

Propargyl-PEG5-amine

Propargyl-PEG5-amine

Ref: IN-DA00HYIF

Propargyl-PEG5-amine

Ref: 54-BIPG1726

Propargyl-PEG5-amine

Ref: TM-T16636

3,6,9,12,15-Pentaoxaoctadec-17-yn-1-amine

Ref: 10-F867265