CAS 159351-68-5

Everolimus O-Silyl Impurity

CAS: 159351-68-5

Formula: C₅₉H₉₇NO₁₄Si

Molecular weight: 1072.50

Ref: 4Z-E-1013

42-O-tert-Butyldimethylsilyloxyethyl Rapamycin

CAS: 159351-68-5

Stability Hygroscopic
Applications 42-O-tert-Butyldimethylsilyloxyethyl Rapamycin is a useful synthetic intermediate in the synthesis of Everolimus (E945400); an immunosuppressant macrolide and analog of the parent drug Rapamycin (R124000). Everolimus inhibits cytokine-mediated lymphocyte proliferation.
References Dumont, F.J., et al.: Curr. Opin. Invest. Drugs, 2, 1220 (2001); Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (2001); Nashan, B., et al.: Ther. Drug Monit., 24, 53 (2002); Venkata, S.P., et al.: PCT Int. Appl. WO 2012066502 A1 20120524. May 24, 2012

Formula: C₅₉H₉₇NO₁₄Si

Color and Shape: Neat

Molecular weight: 1072.48

Ref: TR-B691475

42-o-tert-Butyldimethylsilyloxyethyl rapamycin

CAS: 159351-68-5

Rapamycin is a natural product from Streptomyces hygroscopicus. It has been shown to inhibit T- and B-lymphocyte proliferation, induce apoptosis of lymphocytes, and suppress both humoral and cell-mediated immune responses. Rapamycin is also an immunosuppressant that decreases the incidence of rejection in organ transplant patients. Rapamycin is used as a drug product in the form of a sterile solution for injection. The purity of rapamycin should be at least 99%, with less than 1% impurities, such as 42-O-tert-butyldimethylsilyloxyethyl rapamycin (TBDMS). Rapamycin is not currently available on the market as an API, but it may be custom synthesized for research purposes or for clinical trials.

Formula: C₅₉H₉₇NO₁₄Si

Purity: Min. 95%

Molecular weight: 1,072.49 g/mol

Ref: 3D-JGA35168

Everolimus t-Butyldimethylsilyl Ether

CAS: 159351-68-5

Formula: C₅₉H₉₇NO₁₄Si

Molecular weight: 1072.5

Ref: ST-EA-CP-E33007