CAS 159519-65-0

Enfuvirtide

Description:

Enfuvirtide, also known by its developmental code T-20, is a synthetic peptide that functions as an antiretroviral medication primarily used in the treatment of HIV infection. It is classified as a fusion inhibitor, which means it prevents the virus from entering human cells by interfering with the fusion of the viral and cellular membranes. Enfuvirtide is administered via subcutaneous injection due to its peptide nature, which makes it unsuitable for oral administration. The substance has a molecular formula that reflects its peptide structure, consisting of a sequence of amino acids that contribute to its biological activity. Its mechanism of action involves binding to the gp41 subunit of the HIV envelope glycoprotein, thereby blocking the conformational changes necessary for viral entry. Enfuvirtide is typically used in combination with other antiretroviral agents in treatment-experienced patients who have limited treatment options. Common side effects may include injection site reactions, nausea, and fatigue. Overall, Enfuvirtide represents a critical component in the therapeutic arsenal against HIV, particularly in cases of drug resistance.

Formula: C₂₀₄H₃₀₁N₅₁O₆₄

InChI: InChI=1/C204H301N51O64/c1-20-102(15)166(253-195(310)137(75-100(11)12)239-200(315)150(93-258)251-190(305)143(82-112-90-215-95-219-112)248-203(318)167(103(16)21-2)254-196(311)138(76-101(13)14)240-201(316)151(94-259)252-204(319)168(105(18)260)255-197(312)139(221-106(19)261)78-108-45-47-113(262)48-46-108)202(317)233-131(58-68-164(280)281)178(293)228-130(57-67-163(278)279)182(297)250-149(92-257)198(313)232-125(52-62-155(210)266)179(294)245-145(84-157(212)268)191(306)229-124(51-61-154(209)265)175(290)224-122(49-59-152(207)263)173(288)226-126(53-63-159(270)271)176(291)222-120(43-31-33-69-205)172(287)244-144(83-156(211)267)192(307)231-127(54-64-160(272)273)177(292)225-123(50-60-153(208)264)174(289)227-128(55-65-161(274)275)180(295)235-134(72-97(5)6)185(300)237-133(71-96(3)4)184(299)230-129(56-66-162(276)277)181(296)236-135(73-98(7)8)187(302)247-147(86-165(282)283)194(309)223-121(44-32-34-70-206)171(286)241-140(79-109-87-216-117-40-28-25-37-114(109)117)183(298)220-104(17)170(285)249-148(91-256)199(314)238-136(74-99(9)10)186(301)242-142(81-111-89-218-119-42-30-27-39-116(111)119)189(304)246-146(85-158(213)269)193(308)243-141(80-110-88-217-118-41-29-26-38-115(110)118)188(303)234-132(169(214)284)77-107-35-23-22-24-36-107/h22-30,35-42,45-48,87-90,95-105,120-151,166-168,216-218,256-260,262H,20-21,31-34,43-44,49-86,91-94,205-206H2,1-19H3,(H2,207,263)(H2,208,264)(H2,209,265)(H2,210,266)(H2,211,267)(H2,212,268)(H2,213,269)(H2,214,284)(H,215,219)(H,220,298)(H,221,261)(H,222,291)(H,223,309)(H,224,290)(H,225,292)(H,226,288)(H,227,289)(H,228,293)(H,229,306)(H,230,299)(H,231,307)(H,232,313)(H,233,317)(H,234,303)(H,235,295)(H,236,296)(H,237,300)(H,238,314)(H,239,315)(H,240,316)(H,241,286)(H,242,301)(H,243,308)(H,244,287)(H,245,294)(H,246,304)(H,247,302)(H,248,318)(H,249,285)(H,250,297)(H,251,305)(H,252,319)(H,253,310)(H,254,311)(H,255,312)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,282,283)/t102-,103-,104-,105+,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,166-,167-,168-/m0/s1

Synonyms:

• T-2
• Enfuvirtide(T-20)
• Enfurvitide(T-20)
• Pentafuside
• Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile-Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn-Trp-Phe-NH{2}
• 1-{[19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-(butan-2-yl)-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}prolyl-N~5~-(diaminomethylidene)ornithylglycinamide
• Enfuvirtide Acetate

Enfuvirtide

CAS: 159519-65-0

Enfuvirtide is a 36 amino acid peptide corresponding to a region of gp41, the transmembrane subunit of HIV-1 envelope protein. It belongs to the therapeutic class of fusion inhibitors and acts by binding to gp41 and impeding the conformational changes in gp41 necessary for fusion of the virus with the cell.

Formula: C₂₀₄H₃₀₁N₅₁O₆₄

Purity: ≥ 94%

Color and Shape: White Powder

Molecular weight: 4491.94

Ref: 01-4062216

L-Phenylalaninamide,N-acetyl-L-tyrosyl-L-threonyl-L-seryl-L-leucyl-L-isoleucyl-L-histidyl-L-seryl-L-leucyl-L-isoleucyl-L-a-glutamyl-L-a-glutamyl-L-seryl-L-glutaminyl-L-asparaginyl-L-glutaminyl-L-glutaminyl-L-a-glutamyl-L-lysyl-L-asparaginyl-L-a-glutamyl-L-glutaminyl-L-a-glutamyl-L-leucyl-L-leucyl-L-a-glutamyl-L-leucyl-L-a-aspart

CAS: 159519-65-0

Formula: C₂₀₄H₃₀₁N₅₁O₆₄

Purity: 99%

Color and Shape: Solid

Molecular weight: 4491.8760

Ref: IN-DA01DQA6

Enfuvirtide T-20

CAS: 159519-65-0

Enfuvirtide T-20

Purity: >97.0% as determined by (Typical Value in Batch COA)

Color and Shape: White Lyophilised Powder

Molecular weight: 4,491.88g/mol

Ref: 54-BITP1540

Enfuvirtide

CAS: 159519-65-0

Enfuvirtide (INN) is an HIV fusion inhibitor, the first of a class of antiretroviral drugs used in combination therapy for the treatment of HIV-1 infection.

Formula: C₂₀₄H₃₀₁N₅₁O₆₄

Purity: 98%

Color and Shape: White To Off-White Amorphous Solid

Molecular weight: 4491.945

Ref: TM-TP1332

Enfuvirtide

CAS: 159519-65-0

Formula: C₂₀₄H₃₀₁N₅₁O₆₄

Purity: 95%~99%

Color and Shape: White to Off-white Powder

Molecular weight: 4491.88

Ref: BP-BPPG026

Enfuvirtide

CAS: 159519-65-0

TFA salt. Enfuviritide is a bicyclic heterocycle that is used in the treatment of HIV/AIDS. It binds to the HIV-1 envelope protein, preventing it from binding to CD4+ cells and infecting them. Enfuviritide has been shown to be effective at increasing the levels of active antiretroviral therapy and has shown significant cytotoxicity against HIV-1 and other infectious viruses. This drug also inhibits viral life by binding to the viral envelope protein gp120 and preventing it from binding to CD4+ cells. However, this drug may have long-term toxicity and may cause drug interactions with other drugs that are metabolized by cytochrome P450 enzymes. Enfuviritide has inhibitory properties against a wide range of antimicrobial agents including Gram-positive bacteria, Gram-negative bacteria, fungi, protozoa, and enveloped viruses.

Formula: C₂₀₄H₃₀₁N₅₁O₆₄

Purity: Min. 95%

Molecular weight: 4,491.98 g/mol

Ref: 3D-ENF-3787-PI