CAS 159639-78-8

Uridine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-[(1,1-dimethylethyl)dimethylsilyl]-5-methyl-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

Description:

Uridine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-[(1,1-dimethylethyl)dimethylsilyl]-5-methyl-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] is a complex nucleoside derivative primarily used in the field of molecular biology and biochemistry, particularly in the synthesis of oligonucleotides. This compound features a uridine base, which is a nucleoside composed of a ribose sugar and a uracil base, modified with various functional groups that enhance its stability and reactivity. The presence of the phosphoramidite group allows for efficient coupling reactions in oligonucleotide synthesis, making it a valuable building block for creating RNA sequences. The silyl protection groups contribute to the stability of the molecule during synthesis, while the methoxyphenyl substituents may improve solubility and facilitate handling. Overall, this compound exemplifies the intricate design of nucleoside analogs that are tailored for specific applications in genetic research and therapeutic development.

Formula: C₄₆H₆₃N₄O₉PSi

InChI: InChI=1S/C46H63N4O9PSi/c1-31(2)50(32(3)4)60(56-28-16-27-47)58-40-39(57-43(41(40)59-61(11,12)45(6,7)8)49-29-33(5)42(51)48-44(49)52)30-55-46(34-17-14-13-15-18-34,35-19-23-37(53-9)24-20-35)36-21-25-38(54-10)26-22-36/h13-15,17-26,29,31-32,39-41,43H,16,28,30H2,1-12H3,(H,48,51,52)/t39-,40-,41-,43-,60?/m1/s1

InChI key: InChIKey=KYRSLFQMFXXGLW-IEXCOMMKSA-N

SMILES: C(OC[C@@H]1[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](O[Si](C(C)(C)C)(C)C)[C@@H](O1)N2C(=O)NC(=O)C(C)=C2)(C3=CC=C(OC)C=C3)(C4=CC=C(OC)C=C4)C5=CC=CC=C5

Synonyms:

• Uridine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-[(1,1-dimethylethyl)dimethylsilyl]-5-methyl-, 3′-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
• Uridine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-[(1,1-dimethylethyl)dimethylsilyl]-5-methyl-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
• 5'-O-DMT-2'-O-TBDMS-5-Methy-L-Uridine 3'-CE phosphoramidite
• 5-methy-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-uridine-3'-cyanoethyl-Phosphoramidite

(2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosph

CAS: 159639-78-8

(2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosph

Purity: 95%

Molecular weight: 875.09g/mol

Ref: 54-OR1047326

2'-O-tert-Butyldimethylsilyl-5'-O-DMT-5-methyluridine 3'-CE phosphoramidite

CAS: 159639-78-8

2'-O-tert-Butyldimethylsilyl-5'-O-DMT-5-methyluridine 3'-CE phosphoramidite is a novel DNA synthesis building block that contains a 5'-dimethoxytrityl group. This compound is an activator, which means it helps in the initiation of DNA synthesis. It is used to synthesize oligonucleotides with 5'-terminal deoxyribonucleoside monophosphates and 5'-terminal diphosphates. The 2'-O-tert-butyldimethylsilyl-5'-O-DMT-5-methyluridine 3'-ce phosphoramidite is an anticancer agent, antiviral agent, and an antifungal agent.

Formula: C₄₆H₆₃N₄O₉PSi

Purity: Min. 95%

Molecular weight: 875.07 g/mol

Ref: 3D-PB10513