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CAS 1597-78-0

:

21-Acetoxy-9-fluoro-11β-hydroxy-16α-methylpregna-1,4-diene-3,20-dione

Description:
21-Acetoxy-9-fluoro-11β-hydroxy-16α-methylpregna-1,4-diene-3,20-dione, commonly known as fluocinolone acetonide, is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties. It is characterized by its structural features, including a fluorine atom at the 9-position and an acetoxy group at the 21-position, which enhance its potency and stability. This compound is typically used in dermatological formulations to treat various skin conditions, such as eczema and psoriasis, due to its ability to reduce inflammation and suppress immune responses. Fluocinolone acetonide exhibits a high affinity for glucocorticoid receptors, leading to its effectiveness in modulating gene expression related to inflammation. It is generally administered topically, and its pharmacokinetics can vary based on the formulation and application method. Safety profiles indicate potential side effects, including skin atrophy and local irritation, particularly with prolonged use. Overall, fluocinolone acetonide is a valuable therapeutic agent in the management of inflammatory skin disorders.
Formula:C24H31FO5
InChI:InChI=1S/C24H31FO5/c1-13-9-18-17-6-5-15-10-16(27)7-8-23(15,4)24(17,25)20(29)11-22(18,3)21(13)19(28)12-30-14(2)26/h7-8,10,13,17-18,20-21,29H,5-6,9,11-12H2,1-4H3/t13-,17+,18+,20+,21-,22+,23+,24+/m1/s1
InChI key:InChIKey=HRPWQACPJGPYRH-XHFUFBBFSA-N
SMILES:F[C@@]12[C@]([C@]3([C@](C)(C[C@@H]1O)[C@@H](C(COC(C)=O)=O)[C@H](C)C3)[H])(CCC=4[C@]2(C)C=CC(=O)C4)[H]
Synonyms:
  • Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9-fluoro-11-hydroxy-16-methyl-, (11β,16α)-
  • (11β,16α)-21-(Acetyloxy)-9-fluoro-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione
  • Pregna-1,4-diene-3,20-dione, 9α-fluoro-11β,21-dihydroxy-16α-methyl-, 21-acetate
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,21-dihydroxy-16α-methyl-, 21-acetate
  • 9α-Fluoro-16α-methylpregna-1,4-diene-11β,21-diol-3,20-dione-21-acetate
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Found 5 products.