CAS 159776-70-2

Melagatran

Description:

Melagatran is a synthetic anticoagulant that functions as a direct thrombin inhibitor, primarily used in the prevention and treatment of thromboembolic disorders. It is characterized by its ability to inhibit thrombin, an enzyme crucial for blood clot formation, thereby reducing the risk of clot-related complications. Melagatran is typically administered orally and has a relatively short half-life, necessitating careful dosing and monitoring. The substance is known for its favorable pharmacokinetic profile, including predictable anticoagulant effects, which can be advantageous in clinical settings. However, its use may be associated with potential side effects, such as bleeding complications, which require vigilance during treatment. Melagatran's development was part of a broader effort to create more effective and safer anticoagulants compared to traditional therapies like warfarin. While it has shown promise in clinical trials, its availability and use may vary by region and regulatory approval status. Overall, Melagatran represents an important advancement in anticoagulant therapy, reflecting ongoing research in the field of hematology.

Formula: C₂₂H₃₁N₅O₄

InChI: InChI=1S/C22H31N5O4/c23-20(24)16-8-6-14(7-9-16)12-26-21(30)17-10-11-27(17)22(31)19(25-13-18(28)29)15-4-2-1-3-5-15/h6-9,15,17,19,25H,1-5,10-13H2,(H3,23,24)(H,26,30)(H,28,29)/t17-,19+/m0/s1

InChI key: InChIKey=DKWNMCUOEDMMIN-PKOBYXMFSA-N

SMILES: C([C@H](NCC(O)=O)C1CCCCC1)(=O)N2[C@H](C(NCC3=CC=C(C(=N)N)C=C3)=O)CC2

Synonyms:

• Glycine, N-[(1R)-2-[(2S)-2-[[[[4-(aminoiminomethyl)phenyl]methyl]amino]carbonyl]-1-azetidinyl]-1-cyclohexyl-2-oxoethyl]-
• Glycine, N-[2-[2-[[[[4-(aminoiminomethyl)phenyl]methyl]amino]carbonyl]-1-azetidinyl]-1-cyclohexyl-2-oxoethyl]-, [S-(R*,S*)]-
• H-319/68
• N-[(1R)-2-[(2S)-2-[[[[4-(Aminoiminomethyl)phenyl]methyl]amino]carbonyl]-1-azetidinyl]-1-cyclohexyl-2-oxoethyl]glycine
• N-[(1R)-2-{(2S)-2-[(4-carbamimidoylbenzyl)carbamoyl]azetidin-1-yl}-1-cyclohexyl-2-oxoethyl]glycine
• Melagatran

Glycine, N-[(1R)-2-[(2S)-2-[[[[4-(aminoiminomethyl)phenyl]methyl]amino]carbonyl]-1-azetidinyl]-1-cyclohexyl-2-oxoethyl]-

CAS: 159776-70-2

Formula: C₂₂H₃₁N₅O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 429.5126

Ref: IN-DA001RE6

Melagatran

CAS: 159776-70-2

Melagatran

Purity: ≥98%

Molecular weight: 429.51g/mol

Ref: 54-BUP11663

Melagatran

CAS: 159776-70-2

Formula: C₂₂H₃₁N₅O₄

Molecular weight: 429.52

Ref: 4Z-M-318001

Melagatran-d11

CAS: 159776-70-2

Formula: C₂₂H₂₀D₁₁N₅O₄

Molecular weight: 440.59

Ref: 4Z-M-318002

Melagatran

Controlled Product

CAS: 159776-70-2

Stability Hygroscopic
Applications Synthetic thrombin inhibitor. Thrombin mutant anticoagulant antagonist. Antithrombotic.
References Dewanjee, M., et al.: J. Nucl. Med., 22, 981 (1981), Goodman, S., et al.: J. Biomed. Mater. Res., 45, 240 (1999), Carlsson, S., et al.: Thromb. Res., 115, 9 (2005),

Formula: C₂₂H₃₁N₅O₄

Color and Shape: Neat

Molecular weight: 429.51

Ref: TR-M208450

Melagatran-d11

Controlled Product

CAS: 159776-70-2

Formula: C₂₂D₁₁H₂₀N₅O₄

Color and Shape: Neat

Molecular weight: 440.58

Ref: TR-M208452

Melagatran

CAS: 159776-70-2

Melagatran is an orally available, direct synthetic thrombin inhibitor that does not require endogenous cofactors other than thrombin.Cost-effective and quality-assured.

Formula: C₂₂H₃₁N₅O₄

Purity: 98.29% - >99.99%

Color and Shape: Solid

Molecular weight: 429.51

Ref: TM-T11994