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CAS 159997-94-1

:

Biricodar

Description:
Biricodar, also known by its chemical name, is a small molecule that functions primarily as a multidrug resistance modulator. It is characterized by its ability to inhibit the activity of certain ATP-binding cassette (ABC) transporters, particularly P-glycoprotein (P-gp), which is often overexpressed in various cancer cells. This overexpression can lead to reduced efficacy of chemotherapeutic agents, making Biricodar a potential candidate for enhancing the effectiveness of cancer treatments. The substance is typically administered in a clinical setting and has been investigated in combination with other anticancer drugs to improve therapeutic outcomes. Its mechanism of action involves the reversal of drug resistance, allowing for increased intracellular concentrations of chemotherapeutic agents. Biricodar has undergone various clinical trials to assess its safety, tolerability, and efficacy in different cancer types. As with many investigational drugs, its use is subject to ongoing research to better understand its pharmacokinetics, optimal dosing regimens, and potential side effects.
Formula:C34H41N3O7
InChI:InChI=1S/C34H41N3O7/c1-41-29-20-26(21-30(42-2)32(29)43-3)31(38)33(39)37-19-5-4-16-28(37)34(40)44-27(14-6-10-24-12-8-17-35-22-24)15-7-11-25-13-9-18-36-23-25/h8-9,12-13,17-18,20-23,27-28H,4-7,10-11,14-16,19H2,1-3H3/t28-/m0/s1
InChI key:InChIKey=CGVWPQOFHSAKRR-NDEPHWFRSA-N
SMILES:C(C(=O)C1=CC(OC)=C(OC)C(OC)=C1)(=O)N2[C@H](C(OC(CCCC=3C=CC=NC3)CCCC=4C=CC=NC4)=O)CCCC2
Synonyms:
  • 2-Piperidinecarboxylic acid, 1-[2-oxo-2-(3,4,5-trimethoxyphenyl)acetyl]-, 4-(3-pyridinyl)-1-[3-(3-pyridinyl)propyl]butyl ester, (2S)-
  • 2-Piperidinecarboxylic acid, 1-[oxo(3,4,5-trimethoxyphenyl)acetyl]-, 4-(3-pyridinyl)-1-[3-(3-pyridinyl)propyl]butyl ester, (2S)-
  • 2-Piperidinecarboxylic acid, 1-[oxo(3,4,5-trimethoxyphenyl)acetyl]-, 4-(3-pyridinyl)-1-[3-(3-pyridinyl)propyl]butyl ester, (S)-
  • 4-pyridin-3-yl-1-(3-pyridin-3-ylpropyl)butyl (2S)-1-[oxo(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxylate
  • Incel
  • Vx-710
  • Biricodar
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