CAS 16009-13-5

Hemin

Description:

Hemin, with the CAS number 16009-13-5, is a heme derivative that plays a significant role in various biochemical processes. It is characterized by its dark brown to black crystalline appearance and is soluble in organic solvents such as dimethyl sulfoxide (DMSO) and slightly soluble in water, particularly at acidic pH. Hemin is the oxidized form of heme, which contains an iron ion coordinated to a porphyrin ring. This compound is known for its ability to participate in redox reactions and can act as a catalyst in various biochemical pathways. Hemin is often used in laboratory settings for studies related to hemoglobin and myoglobin, as well as in the synthesis of other heme-containing compounds. Additionally, it has applications in medicine, particularly in the treatment of certain porphyrias, where it helps to regulate heme synthesis. Its stability and reactivity make it a valuable compound in both research and clinical contexts.

Formula: C₃₄H₃₀ClFeN₄O₄·2H

InChI: InChI=1S/C34H34N4O4.ClH.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);1H;/q;;+3/p-3/b25-13-,26-13?,27-14?,28-15?,29-14-,30-15-,31-16-,32-16?;;

InChI key: InChIKey=BTIJJDXEELBZFS-KKXYAJQKSA-K

SMILES: [Cl-][Fe+3]123[N-]4C5=CC6=[N]1C(=CC=7[N-]2C(C=C8[N]3=C(C=C4C(C)=C5CCC([O-])=O)C(C=C)=C8C)=C(C=C)C7C)C(C)=C6CCC([O-])=O.[H+]

Synonyms:

• 1,3,5,8-Tetramethyl-2,4-divinylporphine-6,7-dipropionic acid ferrichloride
• 21H,23H-Porphine-2,18-dipropanoic acid, 7,12-diethenyl-3,8,13,17-tetramethyl-, iron complex
• Chloro[dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-)]iron
• Chlorohemin
• Chloroprotoferriheme
• Chloroprotohemin
• Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24]-, dihydrogen, (SP-5-13)-
• Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N²¹,N²²,N²³,N²⁴]-, dihydrogen, (SP-5-13)-
• Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN21,κN22,κN23,κN24]-, hydrogen (1:2), (SP-5-13)-
• Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN²¹,κN²²,κN²³,κN²⁴]-, dihydrogen, (SP-5-13)-
• Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN²¹,κN²²,κN²³,κN²⁴]-, hydrogen (1:2), (SP-5-13)-
• Ferric hemin
• Ferriheme
• Ferriheme chloride
• Ferriporphyrin chloride
• Ferriprotoporphyrin
• Ferriprotoporphyrin IX
• Ferriprotoporphyrin IX chloride
• Haemin
• Hemin
• Hemin IX
• Hemin chloride
• Hemina
• Hemine
• Iron(III) protoporphyrin chloride
• Iron, chloro[dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-)]-
• Kjb 003
• Panhematin
• Protoferriheme
• Protohemin
• Protohemin IX
• Protohemin chloride
• Teichmann's crystals
• Ferrate(2-), chloro(7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-kappaN21,kappaN22,kappaN23,kappaN24)-, hydrogen (1:2), (SP-5-13)-
• Ferrate(2-), chloro(7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-kappaN21,kappaN22,kappaN23,kappaN24)-, dihydrogen, (SP-5-13)-
• Alkaline Hematin D-575
• UNII-743LRP9S7N
• AI3-18784
• Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN21,κN22,κN23,κN24]-, dihydrogen, (SP-5-13)-
• Ferrihaem
• NSC 122707
• Teichmanns crystals
• CCRIS 7061

Hemin (porcine), 97+%

CAS: 16009-13-5

Hemin is used in cellular protection and control mechanism. It stimulates the synthesis of globulin. It is also used to study the bacterial strains and growth conditions, in the short-term colony assays and cell transfections. Further, it is used to treat the symptoms of various porphyrias. In addit

Formula: C₃₄H₃₂ClFeN₄O₄

Purity: 97+%

Color and Shape: Dark purple or brown to black, Crystals or powder or crystalline powder

Molecular weight: 651.95

Ref: 02-A11165

Hemin

CAS: 16009-13-5

Formula: C₃₄H₃₂ClFeN₄O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 651.9403

Ref: IN-DA00HYL2

Hemin, 95%

CAS: 16009-13-5

Formula: C₃₄H₃₂ClFeN₄O₄

Purity: ≥ 95.0%

Color and Shape: Dark blue or dark green to brown-black powder

Molecular weight: 651.95

Ref: 7W-GE0624

Hemin bovine

CAS: 16009-13-5

Hemin bovine

Formula: C₃₄H₃₂ClFeN₄O₄

Purity: 97%

Molecular weight: 651.95g/mol

Ref: 54-BI4570

Hemin

CAS: 16009-13-5

Hemin

Purity: ≥95%

Molecular weight: 651.94g/mol

Ref: 54-BUP18540

Hemin porcine

CAS: 16009-13-5

Hemin porcine

Formula: C₃₄H₃₂ClFeN₄O₄

Color and Shape: Dark Blue Powder

Molecular weight: 651.94g/mol

Ref: 54-BIH1004

Hemin

CAS: 16009-13-5

Formula: C₃₄H₃₂ClFeN₄O₄

Purity: >95%

Color and Shape: Dark Blue

Molecular weight: 651.94

Ref: FT-H651-9

Hemin

CAS: 16009-13-5

Formula: C₃₄H₃₂ClFeN₄O₄

Purity: >95.0%(T)

Color and Shape: Dark green to Dark purple to Black powder to crystal

Molecular weight: 651.95

Ref: 3B-H0008

Hemin, 98%

CAS: 16009-13-5

Formula: C₃₄H₃₂ClFeN₄O₄

Purity: ≥ 98%

Color and Shape: Dark blue to brown-black powder

Molecular weight: 651.95

Ref: 7W-GE9985

Hemin

CAS: 16009-13-5

Hemin (Hemin chloride) is a chlorinated iron-containing porphyrin, a heme oxygenase (HO)-1 inducer.

Formula: C₃₄H₃₂ClFeN₄O₄

Purity: 97.169% - 99.59%

Color and Shape: Dark Purple Crystalline Powder

Molecular weight: 651.94

Ref: TM-T5515

Hemin

CAS: 16009-13-5

Hemin is an iron-containing porphyrin (Fe(III) complex of protoporphyrin IX) and is present in human blood. It plays an important role in immune response by facilitating hemoglobin release, increasing the production of reactive oxygen species (ROS) and promoting bacterial lysis. Hemin is also found in Porphyromonas gingivalis and hemophilus influenza bacteria and it may play a role in their virulence since it serves as an iron source for growing cultures. However, hemin has shown antibacterial properties when it binds to serum albumin and some modified porphyrins, and has been reported to trigger cell death in Porphyromonas gingivalis (an oral pathogen) by reducing the iron uptake. This might affect the levels of free hemin that actively affect the peroxidation of low-density lipoproteins (LDL). To prevent the peroxidation, hemopexin captures these globin-free hemin by binding to it and transporting it to the liver, where it is internalized and degraded.

Formula: C₃₄H₃₂ClFeN₄O₄

Purity: Min. 97 Area-%

Color and Shape: Powder

Molecular weight: 651.94 g/mol

Ref: 3D-FH16318

Hemin

CAS: 16009-13-5

Hemin is an iron-containing porphyrin (Fe(III) complex of protoporphyrin IX) and is present in human blood. It plays an important role in immune response by facilitating hemoglobin release, increasing the production of reactive oxygen species (ROS) and promoting bacterial lysis. Hemin is also found in Porphyromonas gingivalis and hemophilus influenza bacteria and it may play a role in their virulence since it serves as an iron source for growing cultures. However, hemin has shown antibacterial properties when it binds to serum albumin and some modified porphyrins, and has been reported to trigger cell death in Porphyromonas gingivalis (an oral pathogen) by reducing the iron uptake. This might affect the levels of free hemin that actively affect the peroxidation of low-density lipoproteins (LDL). To prevent the peroxidation, hemopexin captures these globin-free hemin by binding to it and transporting it to the liver, where it is internalized and degraded.

Formula: C₃₄H₃₂ClFeN₄O₄

Purity: Min. 97.0 Area-%

Molecular weight: 651.94 g/mol

Ref: 3D-H-1701

Hemin

CAS: 16009-13-5

Hemin is an iron-containing porphyrin (Fe(III) complex of protoporphyrin IX) and is present in human blood. It plays an important role in immune response by facilitating hemoglobin release, increasing the production of reactive oxygen species (ROS) and promoting bacterial lysis. Hemin is also found in Porphyromonas gingivalis and hemophilus influenza bacteria and it may play a role in their virulence since it serves as an iron source for growing cultures. However, hemin has shown antibacterial properties when it binds to serum albumin and some modified porphyrins, and has been reported to trigger cell death in Porphyromonas gingivalis (an oral pathogen) by reducing the iron uptake. This might affect the levels of free hemin that actively affect the peroxidation of low-density lipoproteins (LDL). To prevent the peroxidation, hemopexin captures these globin-free hemin by binding to it and transporting it to the liver, where it is internalized and degraded.

Formula: C₃₄H₃₂ClFeN₄O₄

Purity: 98.0 To 100.0 Area-%

Color and Shape: Powder

Molecular weight: 651.94 g/mol

Ref: 3D-XH181795

Hemin Chloride (Technical grade)

CAS: 16009-13-5

Applications Hemin chloride is a porphyrin complex heme oxygenase-1 inducer with acts in cellular protection and control. At a concentration of 20 mM Hemin chloride demonstrated the significance of heme in myotube maturation by increasing size, number, cross-striations, and contraction frequency and strength of myotubes. The compound has been observed to induce cGMP formation through induction of guanylate cyclase. Hemin chloride has been noted to stimulate calcium-dependent K+ channels and modulate fluid transport and Na+ in the loop of henle in rat studies. Hemin has also been documented to give rise to active chloride secretion in Caco-2 cells. In cadmium injured rat testes, hemin chloride demonstrated anti-apoptotic, antiinflamatory and antioxidant properties. Through reactive oxygen species of ERK
References Vanova, K. et al.: BMC Cancer., 16, 309 (2016); Wang, X. et al.: ACS App. Mat. Inter., 9, 25387 (2017);

Formula: C₃₄H₃₂ClFeN₄O₄

Color and Shape: Neat

Molecular weight: 651.94

Ref: TR-H245648

Hemin (Ferriprotoporphyrin IX chloride), min. 95%

CAS: 16009-13-5

Hemin (Ferriprotoporphyrin IX chloride), min. 95%

Formula: Fe(C₃₄H₃₂N₄O₄)Cl

Purity: min. 95%

Color and Shape: black xtl.

Molecular weight: 651.95

Ref: 08-26-1480

Hemin Chloride cryst. ex. Porcine extrapure, 98%

CAS: 16009-13-5

Formula: C₃₄H₃₂CIFeN₄O₄

Purity: min. 98%

Color and Shape: Dark brownish black to dark blue to grey, Crystalline powder

Molecular weight: 651.96

Ref: SR-98457

Hemin Chloride cryst. ex. Bovine extrapure, 98%

CAS: 16009-13-5

Formula: C₃₄H₃₂CIFeN₄O₄

Purity: min. 98 %

Color and Shape: Dark brownish black, Crystalline powder

Molecular weight: 651.96

Ref: SR-78372

Hemin

CAS: 16009-13-5

Purity: 98%

Molecular weight: 616.18

Ref: 10-F556533

Hemin-d6

Controlled Product

CAS: 16009-13-5

Formula: C₃₄D₆H₂₆ClFeN₄O₄

Color and Shape: Neat

Molecular weight: 657.977

Ref: TR-H245647