CAS 160129-45-3

7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE

Description:

7-Chloro-1,2,3,4-tetrahydro-benzo[b]azepin-5-one is a chemical compound characterized by its bicyclic structure, which includes a benzene ring fused to a seven-membered azepine ring. The presence of a chlorine atom at the 7-position and a ketone functional group at the 5-position contributes to its unique reactivity and potential biological activity. This compound is typically a solid at room temperature and may exhibit moderate solubility in organic solvents, depending on the specific conditions. Its molecular structure suggests potential interactions with biological targets, making it of interest in medicinal chemistry, particularly in the development of pharmaceuticals. The compound may also display specific stereochemical properties due to the presence of multiple chiral centers, influencing its pharmacological profile. As with many chemical substances, safety data sheets should be consulted for handling and toxicity information, as the chlorine substituent may impart certain hazards. Overall, 7-chloro-1,2,3,4-tetrahydro-benzo[b]azepin-5-one represents a class of compounds that could have significant implications in drug discovery and development.

Formula: C₁₀H₁₀ClNO

InChI: InChI=1/C10H10ClNO/c11-7-3-4-9-8(6-7)10(13)2-1-5-12-9/h3-4,6,12H,1-2,5H2

SMILES: C1CC(=O)c2cc(ccc2NC1)Cl

Synonyms:

• 7-Chloro-1,2,3,4-Tetrahydrobenzo[B]Azepin-5-One
• 7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
• 7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one
• 7-chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-ones
• 5H-1-Benzazepin-5-one,7-chloro-1,2,3,4-tetrahydro-
• Tovaptan impurity 24
• 7-chloro-2,3,4,5-tetrahydro-
• H
• 7-chloro-1, 2, 3, 4-benzo [b] AZA Zhuo-5-ketone
• Tolvaptan Impurity 29
• 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepine-5-One
• 7-Chlorobenzo[b]azepan-5-one
• 7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine
• 7-CHLORO-1,2,3,4-TERTRAHYDROBENZO(B) AZEPIN-5-ONE
• 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one &gt
• Tovaptan impurity 29
• 7-chloro-1,2,3,4-tetrahydro-1-benzazepin-5-one
• 7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE
• 7-chloro-1,2,3,4-tetrahydrobenzo [b] aza-5-one
• 7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
• -1-benzazepin-5-one
• 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzozepin-5-one

5H-1-Benzazepin-5-one, 7-chloro-1,2,3,4-tetrahydro-

CAS: 160129-45-3

Formula: C₁₀H₁₀ClNO

Purity: 97%

Color and Shape: Solid

Molecular weight: 195.6455

Ref: IN-DA001RP9

7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one

CAS: 160129-45-3

Formula: C₁₀H₁₀ClNO

Purity: >98.0%(GC)(T)

Color and Shape: White to Light yellow to Green powder to crystal

Molecular weight: 195.65

Ref: 3B-C2896

7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one

CAS: 160129-45-3

7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one

Formula: C₁₀H₁₀ClNO

Purity: 97%

Color and Shape: light yellow solid

Molecular weight: 195.65g/mol

Ref: 54-OR322271

Tolvaptan Impurity 29

CAS: 160129-45-3

Formula: C₁₀H₁₀ClNO

Molecular weight: 195.65

Ref: 4Z-T-6934

7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one

Controlled Product

CAS: 160129-45-3

Applications 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one is an intermediate in the synthesis of Tolvaptan (T536650) (OPC-41061), an orally active nonpeptide arginine vasopressin V2 receptor antagonist
References Kondo, K., et al.: Bioorg. Med. Chem., 7, 1743 (1999);

Formula: C₁₀H₁₀ClNO

Color and Shape: Neat

Molecular weight: 195.65

Ref: TR-C366265

7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one

CAS: 160129-45-3

Formula: C₁₀H₁₀ClNO

Purity: 97%

Color and Shape: Solid

Molecular weight: 195.65

Ref: 10-F077337

7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one

CAS: 160129-45-3

7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one (7CTB) is a synthetic vasopressin analogue that is used as a vasopressin receptor antagonist. It is a competitive inhibitor of the vasopressin V2 receptor and has been shown to be effective in the treatment of diabetes insipidus. 7CTB has also been shown to bind to and inhibit the binding of arginine, an acid binding agent, preventing hydrolysis reactions with other compounds. 7CTB has been shown to be an effective agent for the treatment of congestive heart failure and chronic kidney disease in animal models. The synthesis process involves sulfonylation followed by dieckmann condensation and organic solvent extraction.

Formula: C₁₀H₁₀ClNO

Purity: Min. 95%

Molecular weight: 195.65 g/mol

Ref: 3D-FC51283

Tolvaptan Impurity 22

CAS: 160129-45-3

Formula: C₁₀H₁₀ClNO

Molecular weight: 195.65

Ref: ST-EA-CP-T26028