CAS 16015-69-3

1-(3-Trifluoromethylphenyl)piperazine monohydrochloride

Description:

1-(3-Trifluoromethylphenyl)piperazine monohydrochloride is a chemical compound characterized by its piperazine core, which is a six-membered ring containing two nitrogen atoms. The presence of a trifluoromethyl group attached to the phenyl ring significantly influences its chemical properties, enhancing lipophilicity and potentially affecting its biological activity. This compound is typically encountered as a hydrochloride salt, which improves its solubility in water and facilitates its handling in laboratory settings. It is often studied for its potential pharmacological applications, particularly in the fields of neuroscience and medicinal chemistry, due to its structural similarity to various psychoactive substances. The trifluoromethyl group can also impart unique electronic properties, making it a subject of interest in drug design and development. Safety data sheets should be consulted for handling precautions, as with many chemical substances, it may pose health risks if not managed properly. Overall, 1-(3-Trifluoromethylphenyl)piperazine monohydrochloride represents a versatile compound with significant implications in research and development.

Formula: C₁₁H₁₃F₃N₂·ClH

InChI: InChI=1S/C11H13F3N2.ClH/c12-11(13,14)9-2-1-3-10(8-9)16-6-4-15-5-7-16;/h1-3,8,15H,4-7H2;1H

InChI key: InChIKey=DGNLGWJZZZOYPT-UHFFFAOYSA-N

SMILES: C(F)(F)(F)C=1C=C(C=CC1)N2CCNCC2.Cl

Synonyms:

• (E)-amino{[N'-(4-fluorophenyl)carbamimidoyl]imino}methanaminium chloride
• 1-(3-(trifluoromethyl)phenyl)Piperazine hydrochloride
• 1-(3-Trifluoromethyl)phenylpiperazine monohydrochloride
• 1-(3-Trifluoromethylphenyl)Piperazine Hcl
• 1-(3-Trifluoromethylphenyl)piperazine hydrochloride
• 1-(alpha,alpha,alpha-trifluoro-M-tolyl)-piperazin
• 4-[3-(Trifluoromethyl)Phenyl]Piperazin-1-Ium Chloride
• N-[3-(Trifluoromethyl)-phenyl]-piperazine monohydrochloride
• Piperazine, 1-(α,α,α-trifluoro-m-tolyl)-, monohydrochloride
• Piperazine, 1-[3-(trifluoromethyl)phenyl]-, hydrochloride (1:1)
• Piperazine, 1-[3-(trifluoromethyl)phenyl]-, monohydrochloride

TFMPP HCl (1-(3-Trifluoromethylphenyl)piperazine Hydrochloride)

Controlled Product

CAS: 16015-69-3

Color and Shape: Neat

Ref: 61-FOR1280.03

TFMPP HCl (1-(3-Trifluoromethylphenyl)piperazine Hydrochloride) 1.0 mg/ml in Methanol (as free base)

Controlled Product

CAS: 16015-69-3

Color and Shape: Single Solution

Ref: 61-AMP1280.03-01

3-Trifluoromethylphenylpiperazine.HCl, 1mg/ml in Methanol (as free base)

Controlled Product

CAS: 16015-69-3

Color and Shape: Single Solution

Ref: LP-PPZ-971-HC-1LM

3-Trifluoromethylphenylpiperazine.HCl

Controlled Product

CAS: 16015-69-3

Color and Shape: Neat

Ref: LP-PPZ-971-HC-10

1-(α,α,α-Trifluoro-m-tolyl)piperazine Hydrochloride

Controlled Product

CAS: 16015-69-3

Stability Hygroscopic
Applications Piperazine derivative used as reference materials for forensic laboratories. They affect the central and the autonomic nervous systems, the blood pressure, and smooth muscle.
References Glass, J., et al.: Brain Res., 638, 235 (1994), Gustafson, E., et al.: Br. J. Pharmacol., 117, 657 (1996), Kikuchi, C., et al.: J. Med. Chem., 42, 533 (1999), Knobelman, D., et al.: J. Pharmacol. Exp. Ther., 292, 1111 (2000),

Formula: C₁₁H₁₃F₃N₂·ClH

Color and Shape: White To Off-White

Molecular weight: 266.69

Ref: TR-T793500

1-(3-Trifluoromethylphenyl)piperazine hydrochloride

Controlled Product

CAS: 16015-69-3

1-(3-Trifluoromethylphenyl)piperazine hydrochloride (TFMPP) is a derivative of the piperazine class of drugs. It is structurally similar to other drugs in this class, such as bromopropane, which acts as an agonist of the 5-HT1 receptor. TFMPP has been shown to be an agonist at 5-HT1 receptors and dopamine receptors. It has also been shown to inhibit serotonin uptake and release, and inhibits choline acetyltransferase activity in brain tissue. TFMPP is not active on the 5-HT2 receptor, but does have some affinity for the 5-HT2A receptor. TFMPP has high affinity for the serotonergic system, with selective binding to serotonin transporter proteins in vitro. TFMPP may also have some effect on cholinergic systems through its inhibition of acetylcholinesterase activity.

Formula: C₁₁H₁₄ClF₃N₂

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 266.69 g/mol

Ref: 3D-FT38536

1-(3-Trifluoromethylphenyl)piperazine hydrochloride

CAS: 16015-69-3

Formula: C₁₁H₁₄ClF₃N₂

Color and Shape: Solid

Molecular weight: 266.6905

Ref: IN-DA00327T