CAS 160177-67-3

Granisetron Impurity C

Description:

Granisetron Impurity C, with the CAS number 160177-67-3, is a chemical compound that is recognized as an impurity associated with the antiemetic drug granisetron, which is used primarily to prevent nausea and vomiting caused by chemotherapy and surgery. This impurity is characterized by its specific molecular structure, which may include functional groups that influence its chemical behavior and stability. Typically, impurities like Granisetron Impurity C can affect the purity and efficacy of the main pharmaceutical compound, making their characterization important in drug development and quality control. The compound may exhibit properties such as solubility in various solvents, stability under different pH conditions, and potential interactions with other substances. Analytical techniques such as chromatography and mass spectrometry are often employed to identify and quantify impurities like Granisetron Impurity C in pharmaceutical formulations. Understanding the characteristics of such impurities is crucial for ensuring the safety and effectiveness of the final drug product.

Formula: C₁₇H₂₂N₄O

InChI: InChI=1/C17H22N4O/c1-21-15-8-3-2-7-14(15)16(20-21)17(22)19-13-9-11-5-4-6-12(10-13)18-11/h2-3,7-8,11-13,18H,4-6,9-10H2,1H3,(H,19,22)

SMILES: Cn1c2ccccc2c(C(=O)NC2CC3CCCC(C2)N3)n1

Synonyms:

• 9’-Desmethyl Granisetron (Granisetron Impurity C)
• endo-N-(9-Azabicyclo[3.3.1]non-3-yl)-1-methyl-1H-indazole-3-carboxamide

Granisetron EP Impurity C

CAS: 160177-67-3

Formula: C₁₇H₂₂N₄O

Molecular weight: 298.39

Ref: ST-EA-CP-G16003

9’-Desmethyl Granisetron

CAS: 160177-67-3

Formula: C₁₇H₂₂N₄O

Color and Shape: Solid

Molecular weight: 298.3828

Ref: IN-DA001RQH

N-[(1R,3r,5S)-9-Azabicyclo[3.3.1]non-3-yl]-1-methyl-1H-indazole-3-carboxamide

Controlled Product

CAS: 160177-67-3

Formula: C₁₇H₂₂N₄O

Color and Shape: Neat

Molecular weight: 298.38

Ref: 86-MM0398.03

9’-Desmethyl Granisetron

Controlled Product

CAS: 160177-67-3

Impurity Granisetron EP Impurity C
Applications An impurity in the synthesis of Granisetron Hydrochloride.
References Nishikawa, M., et al.: Drug Metab. Pharmacokin., 19, 280 (2004), Firkusny, L., et al.: Biochem. Pharmacol., 49, 1777 (1995), Sanwald, P., et al.: Drug Metab. Dispos., 24, 602 (1996), Vanderstreene, et al.: J. Labelled Comp. Radiopharm., XLI, 3, 71 (1997),

Formula: C₁₇H₂₂N₄O

Color and Shape: White To Light Yellow

Molecular weight: 298.38

Ref: TR-D292040

N-((3-endo)-9-Azabicyclo[3.3.1]nonan-3-yl)-1-methyl-1H-indazole-3-carboxamide (Granisetron Impurity)

CAS: 160177-67-3

Purity: 97%

Molecular weight: 298.18

Ref: 10-F554229

9'-Desmethyl granisetron

Controlled Product

CAS: 160177-67-3

9'-Desmethyl granisetron is a drug that is structurally related to granisetron, an antiemetic. It has a low affinity for human liver and plasma proteins, which may be due to its structural similarity to the parent compound. 9'-Desmethyl granisetron binds with high affinity to human cytochrome P450 1A2 (CYP1A2) and can inhibit CYP1A2-mediated metabolism of other drugs. The chemical formula of this drug is C14H19N3OS; it has a molecular weight of 247.35 g/mol.

Formula: C₁₇H₂₂N₄O

Purity: Min. 95%

Molecular weight: 298.38 g/mol

Ref: 3D-ID21276