CAS 160205-58-3

Irbesartan N--D-Glucuronide

Description:

Irbesartan N-D-Glucuronide is a metabolite of the antihypertensive drug irbesartan, which belongs to the class of angiotensin II receptor antagonists. This compound is characterized by its glucuronidation, a common phase II metabolic process where a glucuronic acid moiety is conjugated to a drug or its metabolites, enhancing solubility and facilitating excretion. The chemical structure of Irbesartan N-D-Glucuronide includes a glucuronic acid unit linked to the irbesartan molecule, which contributes to its pharmacokinetic properties. This metabolite is typically found in biological fluids following the administration of irbesartan and is important for understanding the drug's metabolism and elimination pathways. Its presence can influence the overall therapeutic effects and side effects of irbesartan, as well as its bioavailability. The compound is generally studied in the context of drug interactions and pharmacogenomics, as variations in glucuronidation can affect individual responses to irbesartan therapy.

Formula: C₃₁H₃₆N₆O₇

InChI: InChI=1/C31H36N6O7/c1-2-3-10-22-32-31(15-6-7-16-31)30(43)36(22)17-18-11-13-19(14-12-18)20-8-4-5-9-21(20)27-33-35-37(34-27)28-25(40)23(38)24(39)26(44-28)29(41)42/h4-5,8-9,11-14,23-26,28,38-40H,2-3,6-7,10,15-17H2,1H3,(H,41,42)/t23-,24-,25-,26?,28+/m1/s1

Synonyms:

• 1-[5-[4'-[(2-Butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl][1,1'-biphenyl]-2-yl]-2H-tetrazol-2-yl]-1-deoxy--D-glucopyranuronic Acid

Irbesartan N2-Glucuronide

CAS: 160205-58-3

Formula: C₃₁H₃₆N₆O₇

Color and Shape: White To Off-White Solid

Molecular weight: 604.66

Ref: 4Z-I-023

Irbesartan N-b-D-glucuronide

CAS: 160205-58-3

Ref: 7W-GC8117

Irbesartan N-β-D-Glucuronide

CAS: 160205-58-3

Applications A metabolite of Irbesartan (M8).
References Cazaubon, C., et al.: J. Pharmacol. Exp. Ther., 265, 826 (1993), Eberhardt, R., et al.: J. Clin. Pharmacol., 33, 1023 (1993), Huskey, S., et al.: Drug Metab. Dispos., 21, 792 (1993), van Den Meiracker, A., et al.: Hypertension, 25, 22 (1995),

Formula: C₃₁H₃₆N₆O₇

Color and Shape: Neat

Molecular weight: 604.65

Ref: TR-I751010

Irbesartan N2-Glucuronide

CAS: 160205-58-3

Formula: C₃₁H₃₆N₆O₇

Molecular weight: 604.66

Ref: ST-EA-CP-I8024

Irbesartan N-b-D-glucuronide

CAS: 160205-58-3

Irbesartan N-b-D-glucuronide is a complex carbohydrate that is a synthetic saccharide. It is an intermediate in the synthesis of irbesartan, which is an angiotensin II receptor antagonist. Irbesartan N-b-D-glucuronide has been shown to have antihypertensive properties, inhibiting the activity of the renin-angiotensin system and increasing blood flow to the kidneys. It also inhibits the growth of cancer cells. This compound can be custom synthesized for your specific needs and purities can be controlled to meet your specifications.

Formula: C₃₁H₃₆N₆O₇

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 604.65 g/mol

Ref: 3D-MI09885