CAS 16037-91-5

Sodium Stibogluconate

Description:

Sodium stibogluconate, with the CAS number 16037-91-5, is a chemical compound that serves primarily as an antiprotozoal agent, particularly in the treatment of leishmaniasis. It is a sodium salt of stibogluconic acid, which is derived from antimony. The compound is typically presented as a white to off-white powder that is soluble in water, making it suitable for intravenous administration. Sodium stibogluconate exhibits a complex mechanism of action, believed to involve the inhibition of glycolysis in the parasites, leading to their death. It is important to note that the use of this compound can be associated with various side effects, including potential toxicity, which necessitates careful monitoring during treatment. Additionally, its efficacy can vary based on the specific strain of the parasite and the geographical region. As with any pharmaceutical agent, it is crucial to adhere to prescribed dosages and guidelines to ensure safety and effectiveness in clinical applications.

Formula: C₁₂H₃₇Na₃O₂₇Sb₂

InChI: InChI=1/2C6H12O7.3Na.12H2O.2Sb/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;;;;;;;;;;;;;;;;;/h2*2-5,7-11H,1H2,(H,12,13);;;;12*1H2;;/q;;3*+1;;;;;;;;;;;;;;/p-3

InChI key: InChIKey=JLLZQBOUMSOGQY-UZVLBLASSA-N

SMILES: O([Sb]1(=O)O[C@]([C@@H](CO)O)([C@H](O)[C@H](C(O)=O)O1)[H])[Sb]2(=O)O[C@]([C@@H](CO)O)([C@H](O)[C@H](C(O)=O)O2)[H].[Na].O

Synonyms:

• (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate
• 1,3,2-Dioxantimonane, <span class="text-smallcaps">D</span>-gluconic acid deriv.
• 1,3,2-Dioxastibinane, <span class="text-smallcaps">D</span>-gluconic acid deriv.
• <span class="text-smallcaps">D</span>-Gluconic acid, 2,4:2′,4′-O-(oxydistibylidyne)bis-, Sb,Sb′-dioxide, trisodium salt, nonahydrate
• <span class="text-smallcaps">D</span>-Gluconic acid, 2,4:2′,4′-O-(oxydistibylidyne)bis-, sodium salt, hydrate (1:3:9)
• <span class="text-smallcaps">D</span>-Gluconic acid, 2,4:2′,4′-O-[oxybis(oxidostibylidyne)]bis-, trisodium salt, nonahydrate
• <span class="text-smallcaps">D</span>-Gluconic acid, cyclic ester with antimonic acid (H₈Sb₂O₉) (2:1), trisodium salt, nonahydrate
• Antimony (V) derivative of sodium gluconate
• Antimony sodium gluconate
• D-Gluconic acid, 2,4:2',4'-O-(oxydistibylidyne)bis-, Sb,Sb'-dioxide, trisodium salt, nonahydrate
• D-Gluconic acid, cyclic ester with antimonic acid (H8Sb2O9) (2:1), trisodium salt, nonahydrate
• Dioxodistiboxane - Hexonic Acid (1:2)
• Estibogluconato sodico
• Estibogluconato sodico [INN-Spanish]
• Estibogluconato sodico [Spanish]
• Hexonic Acid, Antimony Sodium Salt (2:2:3), Dodecahydrate
• Myostibin
• Natrii stibogluconas
• Natrii stibogluconas [INN-Latin]
• Nonahydrate
• Oxo-Oxostibanyloxy-Stibane
• Pentostam
• Sodium stibogluconate [INN:BAN:DCF]
• Solustibosan
• Solustin
• Solusurmin
• Solyusurmin
• Stibanate
• Stibanose
• Stibatin
• Stibinol
• Stibogluconate de sodium
• Stibogluconate de sodium [INN-French]
• Stibogluconate sodique
• Stibogluconate sodium
• Trinatrium bis(gluconato(3)-O2,O3,O4)hydroxooxido-oxy-bis-antimonat(V)
• Trisodium
• Unii-V083S0159D
• D-Gluconic acid, 2,4:2′,4′-O-(oxydistibylidyne)bis-, Sb,Sb′-dioxide, trisodium salt, nonahydrate
• D-Gluconic acid, 2,4:2′,4′-O-(oxydistibylidyne)bis-, sodium salt, hydrate (1:3:9)
• D-Gluconic acid, 2,4:2′,4′-O-[oxybis(oxidostibylidyne)]bis-, trisodium salt, nonahydrate
• Sodium stibogluconate
• 1,3,2-Dioxantimonane, D-gluconic acid deriv.
• d-gluconicacid,2,4:2’,4’-o-(oxydistibylidyne)bis-,sb,sb’-dioxide,trisodium
• Aids007935
• SSG
• NASBV
• Aids-007935
• Sodium Stibogluconate - CAS 16037-91-5 - Calbiochem
• NASB
• Sodium stibagluconate
• Stibogluconate trisodium nonahydrate
• d-gluconicacid,cyclicesterwithantimonicacid(h8sb2o9)(2:1),trisodium
• Antimony(V) sodium gluconate
• salt,nonahydrate
• estibogluconatosodico

Sodium stibogluconate

CAS: 16037-91-5

Sodium stibogluconate (Stibogluconate trisodium nonahydrate) is a potent protein tyrosine phosphatase inhibitor.

Formula: C₁₂H₃₅Na₃O₂₆Sb₂

Purity: 99.3% - 99.95%

Color and Shape: Solid

Molecular weight: 907.88

Ref: TM-T13013

Sodium stibogluconate

CAS: 16037-91-5

Sodium stibogluconate

Purity: ≥98%

Molecular weight: 907.88g/mol

Ref: 54-BUP17415

Sodium Stibogluconate

Controlled Product

CAS: 100817-46-7, 16037-91-5

Stability Hygroscopic
Applications Sodium Stibogluconate is an intermediate used to prepare Dihydropyrido[2,3-d]pyrimidines as a new class of antileishmanial agents.
References Agarwal, A., et al.: Bioorg. Med. Chem., 13, 6678 (20050

Formula: C₁₂H₂₀O₁₇Sb₂•xNa•xH₂O

Color and Shape: Neat

Molecular weight: 679.8

Ref: TR-S670960

Sodium stibogluconate

CAS: 16037-91-5

Sodium stibogluconate is a drug that has been widely used in the treatment of leishmaniasis. It is administered as an intramuscular injection or intravenous infusion, depending on the severity of the infection. The drug targets the parasite by inhibiting its DNA topoisomerase, which disrupts DNA replication and transcription. Clinical data have shown that this drug is effective against infantum and other strains of leishmania.

Formula: C₁₂H₂₀O₁₇Sb₂•(Na)₃•(H₂O)₉

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 910.9 g/mol

Ref: 3D-FS76282

ANTIMONY SODIUM GLUCONATE

CAS: 16037-91-5

Formula: C₁₂H₃₆Na₃O₂₆Sb₂

Purity: 90%

Color and Shape: Solid

Molecular weight: 908.8880

Ref: IN-DA00AONT