Bacitracin A is a polypeptide antibiotic produced by the bacterium Bacillus subtilis. It is primarily known for its effectiveness against Gram-positive bacteria, making it valuable in both clinical and agricultural applications. The compound functions by inhibiting bacterial cell wall synthesis, specifically targeting the dephosphorylation of bactoprenol, a lipid carrier involved in peptidoglycan assembly. Bacitracin A is typically used topically due to its potential nephrotoxicity when administered systemically. It appears as a white to pale yellow powder and is soluble in water, which facilitates its application in ointments and creams. The antibiotic is often combined with other agents, such as neomycin and polymyxin B, to enhance its antimicrobial spectrum. While it is effective against a range of pathogens, its use is limited by the potential for allergic reactions and the development of resistance. Overall, bacitracin A remains an important tool in the treatment of localized infections and in the prevention of bacterial contamination in various settings.

bacithrocin A

160433-47-6: Bacitracin A is a polypeptide antibiotic produced by the bacterium Bacillus subtilis. It is primarily known for its effectiveness against Gram-positive bacteria, making it valuable in both clinical and agricultural applications. The compound functions by inhibiting bacterial cell wall synthesis, specifically targeting the dephosphorylation of bactoprenol, a lipid carrier involved in peptidoglycan assembly. Bacitracin A is typically used topically due to its potential nephrotoxicity when administered systemically. It appears as a white to pale yellow powder and is soluble in water, which facilitates its application in ointments and creams. The antibiotic is often combined with other agents, such as neomycin and polymyxin B, to enhance its antimicrobial spectrum. While it is effective against a range of pathogens, its use is limited by the potential for allergic reactions and the development of resistance. Overall, bacitracin A remains an important tool in the treatment of localized infections and in the prevention of bacterial contamination in various settings.

<p>Bacithrocin C is a thrombin inhibitor that also suppresses factor Xa, trypsin, and papain, with IC50 values of 48 μM, 13 μM, 0.65 μM, and 0.02 μM, respectively.</p>

CAS 160433-47-6

bacithrocin A

Bacithrocin A

Ref: TM-TN10749