CAS 1605-68-1

taxane

Description:

Taxane refers to a class of chemical compounds derived from the yew tree, particularly Taxus species. The specific compound associated with the CAS number 1605-68-1 is paclitaxel, a well-known taxane used primarily in cancer therapy. Paclitaxel is characterized by its complex polycyclic structure, which includes a taxane core with a unique arrangement of functional groups. It exhibits a high degree of lipophilicity, which influences its solubility and bioavailability. The mechanism of action of paclitaxel involves the stabilization of microtubules, preventing their depolymerization, thereby inhibiting cell division and leading to apoptosis in rapidly dividing cancer cells. This property makes it effective against various types of cancers, including ovarian, breast, and lung cancers. Additionally, paclitaxel has a relatively low oral bioavailability, often necessitating intravenous administration. Its side effects can include myelosuppression, neuropathy, and hypersensitivity reactions, which are important considerations in clinical settings. Overall, taxanes like paclitaxel play a significant role in modern oncology due to their potent antitumor activity.

Formula: C₂₀H₃₆

InChI: InChI=1/C20H36/c1-14-7-6-11-20(5)12-10-17-15(2)8-9-16(13-18(14)20)19(17,3)4/h14-18H,6-13H2,1-5H3

InChI key: InChIKey=DKPFODGZWDEEBT-UHFFFAOYSA-N

SMILES: CC12C(CC3C(C)(C)C(CC1)C(C)CC3)C(C)CCC2

Synonyms:

• (4R,4aR,6S,9R,10S,12aR)-Tetradecahydro-4,9,12a,13,13-pentamethyl-6,10-methanobenzocyclodecene
• 6,10-Methanobenzocyclodecene, tetradecahydro-4,9,12a,13,13-pentamethyl-, (4R,4aR,6S,9R,10S,12aR)-
• 6,10-Methanobenzocyclodecene, tetradecahydro-4,9,12a,13,13-pentamethyl-, (4R-(4alpha,4abeta,6alpha,9alpha,10alpha,12aalpha))-
• 6,10-Methanobenzocyclodecene, tetradecahydro-4,9,12a,13,13-pentamethyl-, [4R-(4α,4aβ,6α,9α,10α,12aα)]-
• Taxan
• Taxane
• Paclitaxel Impurity 7

Taxane

Controlled Product

CAS: 1605-68-1

Formula: C₂₀H₃₆

Color and Shape: Neat

Molecular weight: 276.5

Ref: TR-T009800

Taxane

CAS: 1605-68-1

Taxane is a potent cancer-fighting drug that has been shown to be effective against a variety of tumors. It is extracted from the bark of the Pacific yew tree and has been used in chemotherapy for many years. Taxane works by inhibiting cell division and promoting apoptosis, or programmed cell death, in cancer cells. This drug has been found to be effective against a range of cancers including breast, lung, ovarian, and prostate cancers. Taxane can be detected in urine using trypsin digestion and rifampicin treatment followed by liquid chromatography-mass spectrometry analysis. Studies have shown that Taxane analogs can inhibit kinase activity in cancer cells and may have potential as anti-cancer drugs. Astaxanthin, a carotenoid pigment found in algae and seafood, has also been found to enhance the effects of Taxane on cancer cells. Overall, Taxane is an important tool in the fight against cancer and continues to be an active area of research for new inhibitors

Formula: C₂₀H₃₆

Purity: Min. 95%

Molecular weight: 276.5 g/mol

Ref: 3D-BAA60568

Taxane

CAS: 1605-68-1

Formula: C₂₀H₃₆

Molecular weight: 276.51

Ref: 4Z-P-2851