CAS 16064-10-1

6-Hydroxy-4(3H)-quinazolinone

Description:

6-Hydroxy-4(3H)-quinazolinone, with the CAS number 16064-10-1, is a heterocyclic organic compound characterized by a quinazolinone core structure. This compound features a hydroxyl group at the 6-position and a carbonyl group at the 4-position, contributing to its chemical reactivity and potential biological activity. It is typically a white to off-white crystalline solid, soluble in polar solvents such as water and alcohols, which enhances its utility in various applications. The presence of the hydroxyl group can facilitate hydrogen bonding, influencing its interactions in biological systems. This compound has garnered interest in medicinal chemistry due to its potential pharmacological properties, including antimicrobial and anti-inflammatory activities. Additionally, it may serve as a precursor or intermediate in the synthesis of more complex molecules. Its stability and reactivity can be influenced by environmental factors such as pH and temperature, making it important to consider these conditions in practical applications. Overall, 6-Hydroxy-4(3H)-quinazolinone represents a significant compound in both research and potential therapeutic contexts.

Formula: C₈H₆N₂O₂

InChI: InChI=1S/C8H6N2O2/c11-5-1-2-7-6(3-5)8(12)10-4-9-7/h1-4,11H,(H,9,10,12)

InChI key: InChIKey=QJRNXXLTDWMENM-UHFFFAOYSA-N

SMILES: O=C1C=2C(=CC=C(O)C2)NC=N1

Synonyms:

• 4(1H)-Quinazolinone, 6-hydroxy-
• 4(3H)-Quinazolinone, 6-hydroxy-
• 4,6-Dihydroxyquinazoline
• 6-Hydroxy-3,4-Dihydroquinazolone
• 6-Hydroxy-3,4-dihydroquinazolin-4-one
• 6-Hydroxy-3H-quinazolin-4-one
• 6-Hydroxy-4(3H)-quinazolinone
• 6-Hydroxy-4-Quinazolinone
• 6-Hydroxy-4-quinazolone
• 6-Hydroxyquinazolin-4(3H)-One
• 6-Hydroxyquinazolin-4-Ol
• 6-hydroxyquinazolin-4(1H)-one

6-Hydroxy-3,4-dihydroquinazolone

CAS: 16064-10-1

Formula: C₈H₆N₂O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 162.1454

Ref: IN-DA007BQ4

6-Hydroxyquinazolin-4(3H)-one

CAS: 16064-10-1

6-Hydroxyquinazolin-4(3H)-one

Formula: C₈H₆N₂O₂

Purity: 97.5%

Color and Shape: solid

Molecular weight: 162.15g/mol

Ref: 54-OR11423

6-Hydroxyquinazolin-4(1H)-one

CAS: 16064-10-1

6-Hydroxyquinazolin-4(1H)-one

Purity: ≥95%

Molecular weight: 162.15g/mol

Ref: 54-OR400075

6-Hydroxyquinazolin-4(1H)-one

CAS: 16064-10-1

Formula: C₈H₆N₂O₂

Purity: 98%

Molecular weight: 162.148

Ref: 10-F225116

6-Hydroxyquinazolin-4(1H)-one

CAS: 16064-10-1

6-Hydroxyquinazolin-4(1H)-one is a potent inhibitor of the tyrosine kinase, which blocks the growth of cancer cells and tumor progression. It has been shown to inhibit the growth of human esophageal cancer cells in vitro and in vivo. 6-Hydroxyquinazolin-4(1H)-one inhibits the activity of EGFR tyrosine kinase in these cells. This drug also inhibits the cell proliferation induced by lapatinib, a drug that blocks the activity of HER2 protein tyrosine kinase. 6-Hydroxyquinazolin-4(1H)-one is an inhibitor that belongs to the class of dithiocarbamic compounds. It competitively binds to metal ions such as zinc or copper, which are necessary for enzyme activity. In addition, it inhibits cancer cell growth by inhibition of protein synthesis through interference with ribosomes and RNA polymerases.

Formula: C₈H₆N₂O₂

Purity: Min. 95%

Molecular weight: 162.15 g/mol

Ref: 3D-RAA06410