CAS 160707-69-7: Apricitabine

Description: Apricitabine, also known by its developmental code name ATC code, is a nucleoside reverse transcriptase inhibitor (NRTI) primarily investigated for the treatment of HIV infection. It is characterized by its ability to inhibit the reverse transcriptase enzyme, which is crucial for the replication of the HIV virus. The chemical structure of Apricitabine features a modified nucleoside backbone, which enhances its efficacy and resistance profile compared to other NRTIs. Its mechanism of action involves incorporation into the viral DNA, leading to chain termination during viral replication. Apricitabine has shown activity against various HIV strains, including those resistant to other NRTIs. Additionally, it has a favorable pharmacokinetic profile, allowing for once-daily dosing. However, like other antiretroviral agents, it may be associated with side effects, including potential mitochondrial toxicity. Research and clinical trials have explored its safety and effectiveness, contributing to the understanding of HIV treatment regimens. As of the latest updates, Apricitabine has not received widespread approval for clinical use, but it remains a subject of interest in HIV research.

Formula: C₈H₁₁N₃O₃S

InChI: InChI=1S/C8H11N3O3S/c9-5-1-2-11(8(13)10-5)6-4-14-7(3-12)15-6/h1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6-,7-/m1/s1

InChI key: InChIKey=RYMCFYKJDVMSIR-RNFRBKRXSA-N

SMILES: O=C1N=C(N)C=CN1C2SC(OC2)CO

Synonyms:

• (-)-2′-Deoxy-3′-oxa-4′-thiocytidine
• (-)-Bch 10652
• 1,3-Oxathiolane, 2(1H)-pyrimidinone deriv.
• 2(1H)-Pyrimidinone, 4-amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-
• 2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-, (2R-cis)-
• 4-Amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-2(1H)-pyrimidinone
• Avx 754
• Bch 10618
• Spd 754

2(1H)-Pyrimidinone, 4-amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-

CAS: 160707-69-7

• Formula: C₈H₁₁N₃O₃S
• Purity: 95%
• Molecular weight: 229.25624000000002

(-)-2'-Deoxy-3'-oxa-4'-thiocytidine (Apricitabine)

CAS: 160707-69-7

Applications (-)-2'-Deoxy-3'-oxa-4'-thiocytidine (Apricitabine) is a drug that is used in the treatment of HIV aids. …

• Formula: C₈H₁₁N₃O₃S
• Color and Shape: Neat
• Molecular weight: 229.25

(-)-2'-Deoxy-3'-oxa-4'-thiocytidine (apricitabine)

CAS: 160707-69-7

Apricitabine is a nucleoside analog that has been shown to be active against HIV. It …

• Formula: C₈H₁₁N₃O₃S
• Purity: Min. 95%
• Molecular weight: 229.26 g/mol

Apricitabine

CAS: 160707-69-7

Apricitabine (SPD754) is a highly selective and orally active HIV-1 reverse transcriptase inhibitor (Ki=0.08 μM), …

• Formula: C₈H₁₁N₃O₃S
• Purity: 100%
• Color and Shape: Solid
• Molecular weight: 229.26