CAS 160709-02-4

2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-(hydroxymethyl)-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol

Description:

2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-(hydroxymethyl)-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol, identified by its CAS number 160709-02-4, is a synthetic compound that exhibits unique structural features, including a pentitol backbone and functional groups such as a hydroxymethyl group and a triazole moiety. This compound is characterized by its potential biological activity, particularly in the context of medicinal chemistry, where it may serve as a lead compound for the development of pharmaceuticals. The presence of the difluorophenyl group suggests enhanced lipophilicity, which can influence its pharmacokinetic properties. Additionally, the anhydro sugar structure may contribute to its stability and reactivity. The triazole ring is known for its role in various biological applications, including antifungal and antibacterial activities. Overall, this compound's unique combination of features makes it a subject of interest for further research in drug development and related fields.

Formula: C₁₄H₁₅F₂N₃O₂

InChI: InChI=1S/C14H15F2N3O2/c15-11-1-2-12(13(16)3-11)14(4-10(5-20)6-21-14)7-19-9-17-8-18-19/h1-3,8-10,20H,4-7H2/t10-,14+/m1/s1

InChI key: InChIKey=YGEFLWFVJLRJDL-YGRLFVJLSA-N

SMILES: C([C@@]1(C[C@H](CO)CO1)C2=C(F)C=C(F)C=C2)N3C=NC=N3

Synonyms:

• 2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-(hydroxymethyl)-1-(1H-1,2,4-triazol-1-yl)-<span class="text-smallcaps">D</span>-threo-pentitol
• 2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-(hydroxymethyl)-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol
• <span class="text-smallcaps">D</span>-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-(hydroxymethyl)-1-(1H-1,2,4-triazol-1-yl)-
• D-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-(hydroxymethyl)-1-(1H-1,2,4-triazol-1-yl)-

D-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-(hydroxyMethyl)-1-(1H-1,2,4-triazol-1-yl)-

CAS: 160709-02-4

Formula: C₁₄H₁₅F₂N₃O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 295.2846

Ref: IN-DA00AC0G

2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-(hydroxymethyl)-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol

CAS: 160709-02-4

2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-(hydroxymethyl)-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol

Purity: 98%

Ref: 54-PC1001255

Posaconazole Impurity 4

CAS: 160709-02-4

Formula: C₁₄H₁₅F₂N₃O₂

Color and Shape: Off-White Solid

Molecular weight: 295.29

Ref: 4Z-P-3824

((3R,5R)-5-((1H-1,2,4-TRIAZOL-1-YL)METHYL)-5-(2,4-DIFLUOROPHENYL)TETRAHYDROFURAN-3-YL)METHANOL

CAS: 160709-02-4

Purity: 98%

Molecular weight: 295.2900085449219

Ref: 10-F824512

2,​5-​Anhydro-​1,​3,​4-​trideoxy-​2-​C-​(2,​4-​difluorophenyl)​-​4-​(hydroxymethyl)​-​1-​(1H-​1,​2,​4-​triazol-​1-​yl)​-D-​threo-​pentitol

Controlled Product

CAS: 160709-02-4

Impurity Posaconazole Impurity;
Applications 2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-(hydroxymethyl)-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol is building block to synthesize key intermediates towards synthesis of highly active azole antifungals Sch 51048, Sch 56592 and Sch 45012. It is also an impurity/intermediate for posaconazole (P689600).
References Saksena, A., et al.: Tetrahedron Lett., 37, 5657 (1996); Lovey, R., et al.: Tetrahedron Lett., 35, 6047 (1994); Saksena, A., et al.: Tetrahedron Lett., 36, 1787 (1995)

Formula: C₁₄H₁₅F₂N₃O₂

Color and Shape: Neat

Molecular weight: 295.28

Ref: TR-A658770

Posaconazole Impurity 4

CAS: 160709-02-4

Formula: C₁₄H₁₅F₂N₃O₂

Molecular weight: 295.29

Ref: ST-EA-CP-P24039