CAS 1608125-21-8

(αS)-7-Fluoro-α-methyl-N-9H-purin-6-yl-2-(2-pyridinyl)-3-quinolinemethanamine

Description:

(αS)-7-Fluoro-α-methyl-N-9H-purin-6-yl-2-(2-pyridinyl)-3-quinolinemethanamine, with CAS number 1608125-21-8, is a synthetic compound that belongs to the class of purine derivatives. This substance features a complex structure characterized by a purine core, which is a bicyclic structure containing nitrogen atoms, and is substituted with a fluorine atom at the 7-position. The presence of a methyl group at the alpha position and a quinolinemethanamine moiety contributes to its potential biological activity. The pyridine ring enhances its lipophilicity and may influence its interaction with biological targets. This compound is of interest in medicinal chemistry, particularly for its potential applications in pharmacology, possibly as an inhibitor or modulator of specific biological pathways. Its solubility, stability, and reactivity would depend on the functional groups present and the overall molecular conformation. As with many synthetic compounds, further studies would be necessary to fully elucidate its properties and potential therapeutic uses.

Formula: C₂₁H₁₆FN₇

InChI: InChI=1S/C21H16FN7/c1-12(28-21-19-20(25-10-24-19)26-11-27-21)15-8-13-5-6-14(22)9-17(13)29-18(15)16-4-2-3-7-23-16/h2-12H,1H3,(H2,24,25,26,27,28)/t12-/m0/s1

InChI key: InChIKey=KWRYMZHCQIOOEB-LBPRGKRZSA-N

SMILES: [C@H](NC1=C2C(N=CN2)=NC=N1)(C)C=3C(=NC4=C(C3)C=CC(F)=C4)C5=CC=CC=N5

Synonyms:

• N-[(1S)-1-[7-Fluoro-2-(2-pyridinyl)-3-quinolinyl]ethyl]-9H-purin-6-amine
• AMG 319
• (αS)-7-Fluoro-α-methyl-N-9H-purin-6-yl-2-(2-pyridinyl)-3-quinolinemethanamine
• 3-Quinolinemethanamine, 7-fluoro-α-methyl-N-9H-purin-6-yl-2-(2-pyridinyl)-, (αS)-
• ACP 319
• AMG-319;AMG 319;AMG319
• (S)-N-(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine
• (alphaS)-7-Fluoro-alpha-methyl-N-9H-purin-6-yl-2-(2-pyridinyl)-3-quinolinemethanamine
• (αS)--Fluoro-α-methyl-N-9H-purin-6-yl-2-(2-pyridinyl)-3-quinolinemethanamine
• CS-1593
• AMG319
• ACP319

AMG319

CAS: 1608125-21-8

Formula: C₂₁H₁₆FN₇

Purity: 99%

Color and Shape: Solid

Molecular weight: 385.3970

Ref: IN-DA00ABMX

AMG319

CAS: 1608125-21-8

AMG319

Purity: ≥98%

Molecular weight: 385.4g/mol

Ref: 54-BUP09988

AMG319

CAS: 1608125-21-8

AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.

Formula: C₂₁H₁₆FN₇

Purity: 98.9% - 99.24%

Color and Shape: Crystalline Solid

Molecular weight: 385.4

Ref: TM-T6757

AMG 319

CAS: 1608125-21-8

AMG 319 is an inhibitor of the phosphoinositide 3-kinase enzyme subtype PI3K? used medically in immunotherapy and is currently under investigation in clinical trials for cancer treatment.

Purity: Min. 95%

Ref: 3D-FA137646