CAS 160970-54-7

Silodosin

Description:

Silodosin is a pharmaceutical compound primarily used in the treatment of benign prostatic hyperplasia (BPH), a condition characterized by an enlarged prostate. It belongs to the class of medications known as alpha-1 adrenergic antagonists, which work by selectively blocking alpha-1 receptors in the smooth muscle of the prostate and bladder neck, leading to relaxation of these muscles and improved urinary flow. Silodosin is known for its high selectivity for the alpha-1A subtype of adrenergic receptors, which minimizes side effects commonly associated with non-selective alpha blockers. The compound is typically administered orally and has a relatively short half-life, necessitating once-daily dosing. Its chemical structure includes a piperidine ring and a phenyl group, contributing to its pharmacological properties. Common side effects may include dizziness, retrograde ejaculation, and nasal congestion. As with any medication, it is important for patients to consult healthcare professionals for appropriate use and potential interactions with other drugs.

Formula: C₂₅H₃₂F₃N₃O₄

InChI: InChI=1/C25H32F3N3O4/c1-17(30-8-12-34-21-5-2-3-6-22(21)35-16-25(26,27)28)13-18-14-19-7-10-31(9-4-11-32)23(19)20(15-18)24(29)33/h2-3,5-6,14-15,17,30,32H,4,7-13,16H2,1H3,(H2,29,33)/t17-/m1/s1

InChI key: InChIKey=PNCPYILNMDWPEY-QGZVFWFLSA-N

SMILES: C(CCO)N1C=2C(=CC(C[C@H](NCCOC3=C(OCC(F)(F)F)C=CC=C3)C)=CC2C(N)=O)CC1

Synonyms:

• (-)-1-(3-Hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-2,3-di-hydro-1H-indole-7-carboxamide
• (R)-1-(3-Hydroxypropyl)-5-[2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethy l]amino]propyl]indoline-7-carboxamide
• (R)-1-(3-Hydroxypropyl)-5-[2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]indoline-7-carboxamide
• 1-(3-Hydroxypropyl)-5-[(2R)-2-[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethylamino]propyl]-2,3-dihydroindole-7-carboxamide
• 1-(3-Hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-2,3-dihydro-1H-indole-7-carboxamide
• 1H-Indole-7-carboxamide, 2,3-dihydro-1-(3-hydroxypropyl)-5-[2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-, (R)-
• 1H-Indole-7-carboxamide,2,3-dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-
• 2,3-Dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carboxamide
• Kad 3213
• Kmd 3213
• Rapaflo
• Rapallo
• Silodoxin
• Silodyx
• Urief
• Urorec

Silodosin

CAS: 160970-54-7

Drugs with nitrogen hetero-atom(s) only, aromatic or modified aromatic, nesoi

Formula: C₂₅H₃₂F₃N₃O₄

Color and Shape: White Pale Yellow Crystalline Powder

Molecular weight: 495.23449

Ref: 45-1612776

1-(3-hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]-2,3-dihydro-1H-indole-7-carboxamide

CAS: 160970-54-7

Formula: C₂₅H₃₂F₃N₃O₄

Purity: %

Color and Shape: Solid

Molecular weight: 495.5345

Ref: IN-DA001VKM

Silodosin

CAS: 160970-54-7

Silodosin (KAD 3213) is an alpha-Adrenergic Blocker. The mechanism of action of silodosin is as an Adrenergic alpha-Antagonist.

Formula: C₂₅H₃₂F₃N₃O₄

Purity: 99.282% - 99.76%

Color and Shape: Colorless To Pink Solid

Molecular weight: 495.53

Ref: TM-T1504

Silodosin

CAS: 160970-54-7

Silodosin

Purity: 98%

Molecular weight: 495.53g/mol

Ref: 54-PC109029

Silodosin

CAS: 160970-54-7

Formula: C₂₅H₃₂F₃N₃O₄

Color and Shape: White To Off-White Solid

Molecular weight: 495.54

Ref: 4Z-S-251

Silodosin

CAS: 160970-54-7

Silodosin

Purity: ≥98%

Molecular weight: 495.53g/mol

Ref: 54-BUP10428

Silodosin

CAS: 160970-54-7

Formula: C₂₅H₃₂F₃N₃O₄

Purity: >97.0%(GC)(T)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 495.54

Ref: 3B-I1128

Silodosin RS

CAS: 160970-54-7

Color and Shape: White

Ref: 2K-1071100021

Silodosin

CAS: 160970-54-7

Applications Silodosin is an α1a-adrenoceptor antagonist. It is used in treatment of benign prostatic hypertrophy.
References (1) Shibata, K., et al.: Mol. Pharmacol., 48, 250 (1995) (2) Murata, S., et al.: J. Urol., 164, 578 (2000)

Formula: C₂₅H₃₂F₃N₃O₄

Color and Shape: Neat

Molecular weight: 495.53

Ref: TR-S465000

Silodosin

CAS: 160970-54-7

Alpha1-adrenoceptor antagonist; for treatment of benign prostatic hyperplasia

Formula: C₂₅H₃₂F₃N₃O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 495.53 g/mol

Ref: 3D-FS27830

(-)-1-(3-Hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-2,3-di-hydro-1H-indole-7-carboxamide

CAS: 160970-54-7

Formula: C₂₅H₃₂F₃N₃O₄

Purity: 99%

Color and Shape: Liquid, No data available.

Molecular weight: 495.543

Ref: 10-F544694