CAS 160970-54-7: Silodosin

Description: Silodosin is a pharmaceutical compound primarily used in the treatment of benign prostatic hyperplasia (BPH), a condition characterized by an enlarged prostate. It belongs to the class of medications known as alpha-1 adrenergic antagonists, which work by selectively blocking alpha-1 receptors in the smooth muscle of the prostate and bladder neck, leading to relaxation of these muscles and improved urinary flow. Silodosin is known for its high selectivity for the alpha-1A subtype of adrenergic receptors, which minimizes side effects commonly associated with non-selective alpha blockers. The compound is typically administered orally and has a relatively short half-life, necessitating once-daily dosing. Its chemical structure includes a piperidine ring and a phenyl group, contributing to its pharmacological properties. Common side effects may include dizziness, retrograde ejaculation, and nasal congestion. As with any medication, it is important for patients to consult healthcare professionals for appropriate use and potential interactions with other drugs.

Formula: C₂₅H₃₂F₃N₃O₄

InChI: InChI=1S/C25H32F3N3O4/c1-17(30-8-12-34-21-5-2-3-6-22(21)35-16-25(26,27)28)13-18-14-19-7-10-31(9-4-11-32)23(19)20(15-18)24(29)33/h2-3,5-6,14-15,17,30,32H,4,7-13,16H2,1H3,(H2,29,33)/t17-/m1/s1

InChI key: InChIKey=PNCPYILNMDWPEY-QGZVFWFLSA-N

SMILES: O=C(N)C1=CC(=CC2=C1N(CC2)CCCO)CC(NCCOC=3C=CC=CC3OCC(F)(F)F)C

Synonyms:

• (-)-1-(3-Hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-2,3-di-hydro-1H-indole-7-carboxamide
• (R)-1-(3-Hydroxypropyl)-5-[2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethy l]amino]propyl]indoline-7-carboxamide
• (R)-1-(3-Hydroxypropyl)-5-[2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]indoline-7-carboxamide
• 1-(3-Hydroxypropyl)-5-[(2R)-2-[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethylamino]propyl]-2,3-dihydroindole-7-carboxamide
• 1-(3-Hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-2,3-dihydro-1H-indole-7-carboxamide
• 1H-Indole-7-carboxamide, 2,3-dihydro-1-(3-hydroxypropyl)-5-[2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-, (R)-
• 1H-Indole-7-carboxamide,2,3-dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-
• 2,3-Dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carboxamide
• Kad 3213
• Kmd 3213
• Rapaflo
• Rapallo
• Silodoxin
• Silodyx
• Urief
• Urorec
• Silodosin

Silodosin

CAS: 160970-54-7

Drugs with nitrogen hetero-atom(s) only, aromatic or modified aromatic, nesoi

• Formula: C₂₅H₃₂F₃N₃O₄
• Color and Shape: White Pale Yellow Crystalline Powder
• Molecular weight: 495.23449

1H-Indole-7-carboxamide, 2,3-dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-

CAS: 160970-54-7

• Formula: C₂₅H₃₂F₃N₃O₄
• Purity: %
• Color and Shape: Solid
• Molecular weight: 495.5345

Silodosin

CAS: 160970-54-7

Silodosin (KAD 3213) is an alpha-Adrenergic Blocker. The mechanism of action of silodosin is as …

• Formula: C₂₅H₃₂F₃N₃O₄
• Purity: 99.63% - 99.76%
• Color and Shape: Colorless To Pink Solid
• Molecular weight: 495.53

Silodosin

CAS: 160970-54-7

• Formula: C₂₅H₃₂F₃N₃O₄
• Color and Shape: White To Off-White Solid
• Molecular weight: 495.54

Silodosin

CAS: 160970-54-7

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …

• Formula: C₂₅H₃₂F₃N₃O₄
• Color and Shape: Crystalline powder, White to beige
• Molecular weight: 495.54

Silodosin

CAS: 160970-54-7

• Formula: C₂₅H₃₂F₃N₃O₄
• Purity: >97.0%(GC)(T)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 495.54

Silodosin RS

CAS: 160970-54-7

• Color and Shape: White

Silodosin

CAS: 160970-54-7

Applications Silodosin is an α1a-adrenoceptor antagonist. It is used in treatment of benign prostatic hypertrophy. …

• Formula: C₂₅H₃₂F₃N₃O₄
• Color and Shape: Neat
• Molecular weight: 495.53

(-)-1-(3-Hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-2,3-di-hydro-1H-indole-7-carboxamide

CAS: 160970-54-7

• Purity: 98.0%
• Color and Shape: Liquid, No data available.
• Molecular weight: 495.5429992675781

Silodosin

CAS: 160970-54-7

Alpha1-adrenoceptor antagonist; for treatment of benign prostatic hyperplasia

• Formula: C₂₅H₃₂F₃N₃O₄
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 495.53 g/mol