CAS 1609959-45-6

N-[(1S)-2-Hydroxy-3-methyl-1-(2-methylpropyl)-3-buten-1-yl]-carbamic Acid 1,1-Dimethylethyl Ester

Controlled Product

CAS: 1609959-45-6

Applications N-[(1S)-2-Hydroxy-3-methyl-1-(2-methylpropyl)-3-buten-1-yl]-carbamic Acid 1,1-Dimethylethyl Ester is an intermediate in the synthesis of (S)-2-Amino-4-methyl-1-((S)-2-methyloxiran-2-yl)pentan-1-one Trifluoroacetate Salt which is an impurity of carfilzomib (C183460). Carfilzomib is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.
References Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012); Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013); McCormack, P.L., et al.: Drugs., 72, 2023 (2012);

Formula: C₁₄H₂₇NO₃

Color and Shape: Neat

Molecular weight: 257.37

Ref: TR-H949703

Carfilzomib Impurity 49

CAS: 1609959-45-6

Formula: C₁₄H₂₇NO₃

Molecular weight: 257.37

Ref: ST-EA-CP-C153043