CAS 161109-76-8

3',5'-di-O-acetyl-2-fluoro-2'-O-[(trifluoromethyl)sulfonyl]adenosine

Description:

3',5'-di-O-acetyl-2-fluoro-2'-O-[(trifluoromethyl)sulfonyl]adenosine is a modified nucleoside that features several distinctive chemical characteristics. This compound is derived from adenosine, a key building block of nucleic acids, and is characterized by the presence of acetyl groups at the 3' and 5' positions, which enhance its lipophilicity and stability. The incorporation of a fluorine atom at the 2' position and a trifluoromethylsulfonyl group at the 2'-O position introduces significant electronic and steric effects, potentially influencing its biological activity and interactions with nucleic acid targets. The trifluoromethylsulfonyl moiety is known for its ability to enhance the compound's reactivity and solubility in organic solvents. Overall, this compound is of interest in medicinal chemistry and biochemistry, particularly for its potential applications in the development of antiviral agents or as a tool in nucleic acid research. Its unique structural features may also contribute to its selectivity and efficacy in biological systems.

Formula: C₁₅H₁₅F₄N₅O₈S

InChI: InChI=1/C15H15F4N5O8S/c1-5(25)29-3-7-9(30-6(2)26)10(32-33(27,28)15(17,18)19)13(31-7)24-4-21-8-11(20)22-14(16)23-12(8)24/h4,7,9-10,13H,3H2,1-2H3,(H2,20,22,23)/t7-,9-,10-,13-/m1/s1

SMILES: CC(=O)OC[C@@H]1[C@H]([C@H]([C@H](n2cnc3c(N)nc(F)nc23)O1)OS(=O)(=O)C(F)(F)F)OC(=O)C

Synonyms:

• 3',5'-Di-O-acetyl-2-fluoro-2'-O-trifluoro-methanesulfonyladenosine

((2R,3R,4R,5R)-3-Acetoxy-5-(6-amino-2-fluoro-9H-purin-9-yl)-4-(((trifluoromethyl)sulfonyl)oxy)tetrahydrofuran-2-yl)methyl acetate

CAS: 161109-76-8

Formula: C₁₅H₁₅F₄N₅O₈S

Molecular weight: 501.3669

Ref: IN-DA001S6A

3'',5''-Di-O-acetyl-2-fluoro-2''-O-trifluoromethanesulfonyl adenosine

CAS: 161109-76-8

Ref: 7W-GN1409

3',5'-Di-O-acetyl-2-fluoro-2'-O-trifluoromethanesulfonyladenosine

CAS: 161109-76-8

3',5'-Di-O-acetyl-2-fluoro-2'-O-trifluoromethanesulfonyladenosine is a synthetic antiviral agent that inhibits viral replication via the inhibition of viral DNA polymerase. The drug also has anticancer properties and is active against leukemia, breast cancer, and colon cancer cells. 3',5'-Di-O-acetyl-2-fluoro-2'-O-trifluoromethanesulfonyladenosine has been synthesized in a novel manner by the use of modified nucleosides and phosphoramidites. This compound has high purity and quality.

Formula: C₁₅H₁₅F₄N₅O₈S

Purity: Min. 95%

Molecular weight: 501.37 g/mol

Ref: 3D-ND10387