CAS 161302-93-8

(3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)piperidine hydrochloride

Description:

(3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)piperidine hydrochloride is a chemical compound characterized by its piperidine ring structure, which features multiple hydroxyl groups that contribute to its hydrophilic nature. The presence of hydroxyl groups at the 3, 4, and 5 positions enhances its solubility in water and may influence its biological activity. This compound is typically encountered in the form of a hydrochloride salt, which improves its stability and solubility in aqueous solutions. The stereochemistry indicated by the (3R,4R,5R) configuration suggests that it has specific spatial arrangements that can affect its interaction with biological targets, making it of interest in medicinal chemistry. Its potential applications may include roles in pharmaceuticals, particularly in the development of compounds that interact with biological systems, such as enzymes or receptors. As with many piperidine derivatives, it may exhibit various pharmacological properties, although specific activities would depend on further research and characterization.

Formula: C₆H₁₄ClNO₃

Synonyms:

• Isofagomine hydrochloride
• Nn-42-1007

PIM-1 Inhibitor 2

CAS: 161302-93-8

PIM-1 Inhibitor 2

Purity: ≥98%

Molecular weight: 322.75g/mol

Ref: 54-BUP20437

Isofagomine hydrochloride

CAS: 161302-93-8

Inhibitor of lysosomal acid β-glucosidase (GlcCerase/glucocerebrosidase) with IC50 in nanomolar range for wildtype and mutant enzyme. It behaves as pharmacological chaperon by binding to instable GlcCerase active site at neutral pH values and facilitating the protein folding. In acidic lysosomes, isofagomine gets release from the enzyme active site. This results in increased levels of functional glucocerebrosidase and brings therapeutic benefits to patients with Gaucher disease.

Formula: C₆H₁₃NO₃·HCl

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 183.63 g/mol

Ref: 3D-MI45273

Afegostat HCl

CAS: 161302-93-8

Afegostat: GCase inhibitor, Ki ~30 nM for wild-type/mutant, experimental Gaucher's disease drug.

Formula: C₆H₁₄ClNO₃

Color and Shape: Solid

Molecular weight: 183.63

Ref: TM-T23653