NDM-1 inhibitor-5, identified by its CAS number 1613045-02-5, is a chemical compound that serves as an inhibitor of the New Delhi metallo-beta-lactamase-1 (NDM-1) enzyme. This enzyme is known for its role in antibiotic resistance, particularly against a broad range of beta-lactam antibiotics, including carbapenems. The characteristics of NDM-1 inhibitor-5 include its potential to bind to the active site of the NDM-1 enzyme, thereby preventing it from hydrolyzing beta-lactam antibiotics and restoring their efficacy. The compound is typically characterized by its molecular structure, which may include specific functional groups that enhance its binding affinity and selectivity for the target enzyme. Additionally, it may exhibit properties such as solubility in various solvents, stability under physiological conditions, and a defined mechanism of action. Research into NDM-1 inhibitors like this compound is crucial for developing new therapeutic strategies to combat antibiotic-resistant infections.

NDM-1 inhibitor-5

1613045-02-5: NDM-1 inhibitor-5, identified by its CAS number 1613045-02-5, is a chemical compound that serves as an inhibitor of the New Delhi metallo-beta-lactamase-1 (NDM-1) enzyme. This enzyme is known for its role in antibiotic resistance, particularly against a broad range of beta-lactam antibiotics, including carbapenems. The characteristics of NDM-1 inhibitor-5 include its potential to bind to the active site of the NDM-1 enzyme, thereby preventing it from hydrolyzing beta-lactam antibiotics and restoring their efficacy. The compound is typically characterized by its molecular structure, which may include specific functional groups that enhance its binding affinity and selectivity for the target enzyme. Additionally, it may exhibit properties such as solubility in various solvents, stability under physiological conditions, and a defined mechanism of action. Research into NDM-1 inhibitors like this compound is crucial for developing new therapeutic strategies to combat antibiotic-resistant infections.

<p>NDM-1 Inhibitor-5 (compound 57) exhibits strong inhibition of NDM-1, characterized by a K i of 2.5 μM. Additionally, it demonstrates synergistic antibacterial effects when combined with meropenem [1].</p>

CAS 1613045-02-5

NDM-1 inhibitor-5

NDM-1 inhibitor-5

Ref: TM-T86986