CAS 161600-01-7
:Isaglitazone
Description:
Isaglitazone is a synthetic compound belonging to the thiazolidinedione class of medications, primarily used in the management of type 2 diabetes mellitus. It functions as a peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist, which enhances insulin sensitivity and promotes glucose uptake in peripheral tissues. Isaglitazone exhibits anti-inflammatory properties and may also influence lipid metabolism. The compound is characterized by its ability to modulate gene expression related to glucose and lipid homeostasis. Its chemical structure includes a thiazolidinedione ring, which is essential for its biological activity. Isaglitazone has been studied for its potential benefits in improving glycemic control and reducing insulin resistance, although its clinical use may be limited by side effects such as weight gain and potential cardiovascular risks. As with other thiazolidinediones, monitoring for adverse effects is crucial in patients undergoing treatment. Overall, Isaglitazone represents a significant area of research in diabetes pharmacotherapy, contributing to the understanding of metabolic regulation.
Formula:C21H16FNO3S
InChI:InChI=1S/C21H16FNO3S/c22-18-4-2-1-3-16(18)12-26-17-8-7-14-9-13(5-6-15(14)11-17)10-19-20(24)23-21(25)27-19/h1-9,11,19H,10,12H2,(H,23,24,25)
InChI key:InChIKey=PKWDZWYVIHVNKS-UHFFFAOYSA-N
SMILES:C(C1=CC2=C(C=C(OCC3=C(F)C=CC=C3)C=C2)C=C1)C4C(=O)NC(=O)S4
Synonyms:- 2,4-Thiazolidinedione, 5-[[6-[(2-fluorophenyl)methoxy]-2-naphthalenyl]methyl]-
- 5-({6-[(2-Fluorobenzyl)Oxy]Naphthalen-2-Yl}Methyl)-1,3-Thiazolidine-2,4-Dione
- 5-[[6-[(2-Fluorophenyl)Methoxy]-2-Naphthalenyl]Methyl]-2,4-Thiazolidinedione
- Isaglitazone
- Netoglitazone
- Netoglitazone,2,4-Thiazolidinedione, 5-[[6-[(2-Fluorophenyl)Methoxy]-2-Naphthalenyl]Methyl]-
- Rwj 241947
- MCC 555
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