![N-(2-Amino-4-fluorophenyl)-4-[[[(2E)-1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]benzamide](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fcas-image%2Fthumb-webp%2F313962-n-2-amino-4-fluorophenyl-4-2e-1-oxo-3-3-pyridinyl-2-propen-1-yl-amino-methyl-benzamide.webp&w=3840&q=75)
CAS 1616493-44-7
:N-(2-Amino-4-fluorophenyl)-4-[[[(2E)-1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]benzamide
Description:
N-(2-Amino-4-fluorophenyl)-4-[[[(2E)-1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]benzamide, with the CAS number 1616493-44-7, is a synthetic organic compound characterized by its complex structure, which includes an amide functional group, an aromatic system, and a pyridine moiety. This compound features a fluorinated phenyl ring, which can influence its biological activity and lipophilicity. The presence of the amino and carbonyl groups suggests potential for hydrogen bonding, which may enhance its solubility in polar solvents. The compound is likely to exhibit specific pharmacological properties, making it of interest in medicinal chemistry, particularly in the development of therapeutic agents. Its structural components may interact with biological targets, potentially leading to applications in treating various diseases. As with many synthetic compounds, its stability, reactivity, and biological efficacy would depend on the specific conditions under which it is studied, including pH, temperature, and the presence of other chemical species.
Formula:C22H19FN4O2
InChI:InChI=1S/C22H19FN4O2/c23-18-8-9-20(19(24)12-18)27-22(29)17-6-3-16(4-7-17)14-26-21(28)10-5-15-2-1-11-25-13-15/h1-13H,14,24H2,(H,26,28)(H,27,29)/b10-5+
InChI key:InChIKey=SZMJVTADHFNAIS-BJMVGYQFSA-N
SMILES:C(NC1=C(N)C=C(F)C=C1)(=O)C2=CC=C(CNC(/C=C/C=3C=CC=NC3)=O)C=C2
Synonyms:- HBI 8000
- N-(2-Amino-4-fluorophenyl)-4-[[[(2E)-1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]benzamide
- Tucidinostat
- Epidaza
- Benzamide, N-(2-amino-4-fluorophenyl)-4-[[[(2E)-1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]-
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Found 9 products.
(E)-N-(2-Amino-4-Fluorophenyl)-4-((3-(Pyridin-3-Yl)Acrylamido)Methyl)Benzamide
CAS:(E)-N-(2-Amino-4-Fluorophenyl)-4-((3-(Pyridin-3-Yl)Acrylamido)Methyl)BenzamidePurity:97%Molecular weight:390.41g/molChidamide (Tucidinostat)
CAS:Formula:C22H19FN4O2Color and Shape:Off-White SolidMolecular weight:390.42Tucidinostat
CAS:Tucidinostat is an oral HDAC1/2/3/10 inhibitor (IC50: 67-160 nM), weaker on HDAC8/11, inactive on HDAC4/5/6/7/9.Formula:C22H19FN4O2Purity:97.01% - 99.95%Color and Shape:SolidMolecular weight:390.41Chidamide
CAS:Controlled Product<p>Applications Chidamide is a newly designed histone deacetylase inhibitor that induces an antitumor effect in various cancer by increasing the acetylation levels of histone H3 and decrease histone deacetylase (HDAC) activity, induces apoptosis. Also, it is a potential utility of Chidamide for the treatment of Myelodysplastic syndromes.<br>References Liu, Z., et al.: Biomed. Pharmacother., 83, 1032-1027 (2016)<br></p>Formula:C22H19FN4O2Color and Shape:NeatMolecular weight:390.41Tucidinostat
CAS:De-5-fluoro 4-Fluorochidamide is a potent inhibitor of histone deacetylases (HDACs) that was synthesized as a potential anti-cancer agent. The drug inhibits the HDAC enzyme and prevents the methylation of lysine residues on histones, which leads to changes in gene expression. De-5-fluoro 4-Fluorochidamide has been evaluated in clinical studies for its safety and efficacy in the treatment of cancer, but has not yet been approved for use in humans. De-5-fluoro 4-Fluorochidamide has shown thrombocytopenia and other toxicities in animal models at high doses, which can be attributed to its ability to inhibit HSP90.Formula:C22H19FN4O2Purity:Min. 95%Color and Shape:PowderMolecular weight:390.41 g/mol
